Carbogen gas and radiotherapy outcomes in prostate cancer
Prostate cancer hypoxia is associated with inferior prognosis and resistance to treatment. The use of androgen deprivation therapy, both prior to and during radiotherapy, may exacerbate underlying hypoxia. Whilst larger radiation doses per fraction may achieve therapeutic gain, this is balanced by t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2013-02-01
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| Series: | Therapeutic Advances in Urology |
| Online Access: | https://doi.org/10.1177/1756287212452195 |
| _version_ | 1818317823234015232 |
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| author | Kent Yip Roberto Alonzi |
| author_facet | Kent Yip Roberto Alonzi |
| author_sort | Kent Yip |
| collection | DOAJ |
| description | Prostate cancer hypoxia is associated with inferior prognosis and resistance to treatment. The use of androgen deprivation therapy, both prior to and during radiotherapy, may exacerbate underlying hypoxia. Whilst larger radiation doses per fraction may achieve therapeutic gain, this is balanced by the reduced opportunity for re-oxygenation to take place during the course of treatment. Improving the underlying hypoxic tumour environment may therefore improve the treatment outcomes. Strategies to combat tumour hypoxia, with particular focus on the use of carbogen gas breathing concurrently with radiotherapy, is the subject of this review. |
| first_indexed | 2024-12-13T09:43:27Z |
| format | Article |
| id | doaj.art-ee1e0112e34d4c8f85fe0a5ec9f7575c |
| institution | Directory Open Access Journal |
| issn | 1756-2872 1756-2880 |
| language | English |
| last_indexed | 2024-12-13T09:43:27Z |
| publishDate | 2013-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Urology |
| spelling | doaj.art-ee1e0112e34d4c8f85fe0a5ec9f7575c2022-12-21T23:52:08ZengSAGE PublishingTherapeutic Advances in Urology1756-28721756-28802013-02-01510.1177/1756287212452195Carbogen gas and radiotherapy outcomes in prostate cancerKent YipRoberto AlonziProstate cancer hypoxia is associated with inferior prognosis and resistance to treatment. The use of androgen deprivation therapy, both prior to and during radiotherapy, may exacerbate underlying hypoxia. Whilst larger radiation doses per fraction may achieve therapeutic gain, this is balanced by the reduced opportunity for re-oxygenation to take place during the course of treatment. Improving the underlying hypoxic tumour environment may therefore improve the treatment outcomes. Strategies to combat tumour hypoxia, with particular focus on the use of carbogen gas breathing concurrently with radiotherapy, is the subject of this review.https://doi.org/10.1177/1756287212452195 |
| spellingShingle | Kent Yip Roberto Alonzi Carbogen gas and radiotherapy outcomes in prostate cancer Therapeutic Advances in Urology |
| title | Carbogen gas and radiotherapy outcomes in prostate cancer |
| title_full | Carbogen gas and radiotherapy outcomes in prostate cancer |
| title_fullStr | Carbogen gas and radiotherapy outcomes in prostate cancer |
| title_full_unstemmed | Carbogen gas and radiotherapy outcomes in prostate cancer |
| title_short | Carbogen gas and radiotherapy outcomes in prostate cancer |
| title_sort | carbogen gas and radiotherapy outcomes in prostate cancer |
| url | https://doi.org/10.1177/1756287212452195 |
| work_keys_str_mv | AT kentyip carbogengasandradiotherapyoutcomesinprostatecancer AT robertoalonzi carbogengasandradiotherapyoutcomesinprostatecancer |