Common themes in antimicrobial and anticancer drug resistance
Antimicrobial and anticancer drug resistance represent two of the main global challenges for the public health, requiring immediate practical solutions. In line with this, we need a better understanding of the origins of drug resistance in prokaryotic and eukaryotic cells and the evolutionary proces...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.960693/full |
| _version_ | 1811314505071722496 |
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| author | Mariana Carmen Chifiriuc Mariana Carmen Chifiriuc Mariana Carmen Chifiriuc Mariana Carmen Chifiriuc Roxana Filip Roxana Filip Marian Constantin Gratiela Gradisteanu Pircalabioru Gratiela Gradisteanu Pircalabioru Coralia Bleotu Coralia Bleotu Liliana Burlibasa Elena Ionica Nicolae Corcionivoschi Nicolae Corcionivoschi Grigore Mihaescu |
| author_facet | Mariana Carmen Chifiriuc Mariana Carmen Chifiriuc Mariana Carmen Chifiriuc Mariana Carmen Chifiriuc Roxana Filip Roxana Filip Marian Constantin Gratiela Gradisteanu Pircalabioru Gratiela Gradisteanu Pircalabioru Coralia Bleotu Coralia Bleotu Liliana Burlibasa Elena Ionica Nicolae Corcionivoschi Nicolae Corcionivoschi Grigore Mihaescu |
| author_sort | Mariana Carmen Chifiriuc |
| collection | DOAJ |
| description | Antimicrobial and anticancer drug resistance represent two of the main global challenges for the public health, requiring immediate practical solutions. In line with this, we need a better understanding of the origins of drug resistance in prokaryotic and eukaryotic cells and the evolutionary processes leading to the occurrence of adaptive phenotypes in response to the selective pressure of therapeutic agents. The purpose of this paper is to present some of the analogies between the antimicrobial and anticancer drug resistance. Antimicrobial and anticancer drugs share common targets and mechanisms of action as well as similar mechanisms of resistance (e.g., increased drug efflux, drug inactivation, target alteration, persister cells’ selection, protection of bacterial communities/malignant tissue by an extracellular matrix, etc.). Both individual and collective stress responses triggered by the chemotherapeutic agent involving complex intercellular communication processes, as well as with the surrounding microenvironment, will be considered. The common themes in antimicrobial and anticancer drug resistance recommend the utility of bacterial experimental models for unraveling the mechanisms that facilitate the evolution and adaptation of malignant cells to antineoplastic drugs. |
| first_indexed | 2024-04-13T11:13:53Z |
| format | Article |
| id | doaj.art-ee1ef501f22c4ff6b5dddbf2bf995f2a |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T11:13:53Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-ee1ef501f22c4ff6b5dddbf2bf995f2a2022-12-22T02:49:03ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-08-011310.3389/fmicb.2022.960693960693Common themes in antimicrobial and anticancer drug resistanceMariana Carmen Chifiriuc0Mariana Carmen Chifiriuc1Mariana Carmen Chifiriuc2Mariana Carmen Chifiriuc3Roxana Filip4Roxana Filip5Marian Constantin6Gratiela Gradisteanu Pircalabioru7Gratiela Gradisteanu Pircalabioru8Coralia Bleotu9Coralia Bleotu10Liliana Burlibasa11Elena Ionica12Nicolae Corcionivoschi13Nicolae Corcionivoschi14Grigore Mihaescu15Faculty of Biology, University of Bucharest, Bucharest, RomaniaLife, Environmental and Earth Sciences Division, Research Institute of the University of Bucharest, Bucharest, RomaniaThe Romanian Academy, Bucharest, RomaniaAcademy of Romanian Scientists, Bucharest, RomaniaFaculty of Medicine and Biological Sciences, Stefan cel Mare University of Suceava, Suceava, RomaniaSuceava Emergency County Hospital, Suceava, RomaniaInstitute of Biology, Bucharest, RomaniaFaculty of Biology, University of Bucharest, Bucharest, RomaniaAcademy of Romanian Scientists, Bucharest, RomaniaStefan S. Nicolau Institute of Virology, Bucharest, RomaniaRomanian Academy of Scientists, Bucharest, RomaniaFaculty of Biology, University of Bucharest, Bucharest, RomaniaFaculty of Biology, University of Bucharest, Bucharest, Romania0Bacteriology Branch, Veterinary Sciences Division, Agri-Food and Biosciences Institute, Belfast, United Kingdom1Faculty of Bioengineering of Animal Resources, Banat University of Agricultural Sciences and Veterinary Medicine—King Michael I of Romania, Timisoara, RomaniaFaculty of Biology, University of Bucharest, Bucharest, RomaniaAntimicrobial and anticancer drug resistance represent two of the main global challenges for the public health, requiring immediate practical solutions. In line with this, we need a better understanding of the origins of drug resistance in prokaryotic and eukaryotic cells and the evolutionary processes leading to the occurrence of adaptive phenotypes in response to the selective pressure of therapeutic agents. The purpose of this paper is to present some of the analogies between the antimicrobial and anticancer drug resistance. Antimicrobial and anticancer drugs share common targets and mechanisms of action as well as similar mechanisms of resistance (e.g., increased drug efflux, drug inactivation, target alteration, persister cells’ selection, protection of bacterial communities/malignant tissue by an extracellular matrix, etc.). Both individual and collective stress responses triggered by the chemotherapeutic agent involving complex intercellular communication processes, as well as with the surrounding microenvironment, will be considered. The common themes in antimicrobial and anticancer drug resistance recommend the utility of bacterial experimental models for unraveling the mechanisms that facilitate the evolution and adaptation of malignant cells to antineoplastic drugs.https://www.frontiersin.org/articles/10.3389/fmicb.2022.960693/fullmicrobial biofilmspersister cellsefflux pumpsstress responsegut microbiotamutator phenotype |
| spellingShingle | Mariana Carmen Chifiriuc Mariana Carmen Chifiriuc Mariana Carmen Chifiriuc Mariana Carmen Chifiriuc Roxana Filip Roxana Filip Marian Constantin Gratiela Gradisteanu Pircalabioru Gratiela Gradisteanu Pircalabioru Coralia Bleotu Coralia Bleotu Liliana Burlibasa Elena Ionica Nicolae Corcionivoschi Nicolae Corcionivoschi Grigore Mihaescu Common themes in antimicrobial and anticancer drug resistance Frontiers in Microbiology microbial biofilms persister cells efflux pumps stress response gut microbiota mutator phenotype |
| title | Common themes in antimicrobial and anticancer drug resistance |
| title_full | Common themes in antimicrobial and anticancer drug resistance |
| title_fullStr | Common themes in antimicrobial and anticancer drug resistance |
| title_full_unstemmed | Common themes in antimicrobial and anticancer drug resistance |
| title_short | Common themes in antimicrobial and anticancer drug resistance |
| title_sort | common themes in antimicrobial and anticancer drug resistance |
| topic | microbial biofilms persister cells efflux pumps stress response gut microbiota mutator phenotype |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.960693/full |
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