Mechanisms Protecting <i>Acinetobacter baumannii</i> against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment
<i>Acinetobacter baumannii</i> is considered one of the most persistent pathogens responsible for nosocomial infections. Due to the emergence of multidrug resistant strains, as well as high morbidity and mortality caused by this pathogen, <i>A. baumannii</i> was placed on the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/15/5498 |
| Summary: | <i>Acinetobacter baumannii</i> is considered one of the most persistent pathogens responsible for nosocomial infections. Due to the emergence of multidrug resistant strains, as well as high morbidity and mortality caused by this pathogen, <i>A. baumannii</i> was placed on the World Health Organization (WHO) drug-resistant bacteria and antimicrobial resistance research priority list. This review summarizes current studies on mechanisms that protect <i>A. baumannii</i> against multiple stresses caused by the host immune response, outside host environment, and antibiotic treatment. We particularly focus on the ability of <i>A. baumannii</i> to survive long-term desiccation on abiotic surfaces and the population heterogeneity in <i>A. baumannii</i> biofilms. Insight into these protective mechanisms may provide clues for the development of new strategies to fight multidrug resistant strains of <i>A. baumannii</i>. |
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| ISSN: | 1661-6596 1422-0067 |