The subclinical form of experimental visceral leishmaniasis in dogs
Pathological aspects of a subclinical form of experimental canine leishmaniasis is reported here for the first time. Fifteen mongrel dogs were used in the present study. Eight dogs were infected and seven were used as control. Four of the control dogs were inoculated with spleen cells from non-infec...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1993-06-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000200011 |
| _version_ | 1797757078073245696 |
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| author | G. G. S. Oliveira F. Santoro M. Sadigursky |
| author_facet | G. G. S. Oliveira F. Santoro M. Sadigursky |
| author_sort | G. G. S. Oliveira |
| collection | DOAJ |
| description | Pathological aspects of a subclinical form of experimental canine leishmaniasis is reported here for the first time. Fifteen mongrel dogs were used in the present study. Eight dogs were infected and seven were used as control. Four of the control dogs were inoculated with spleen cells from non-infected hamsters. The eight mongrel dogs inoculated intravenously with amastigotes forms of Leishmania chagasi envolved for periods as long as 25 months without any clinical characteristic sign of classical Visceral Leishmaniasis (VL). Most of the laboratory test results were compatible to those of the seven control animals but culture of bone marrow aspirated material and serologic testing (IIF) demonstrated or provided evidence that the animals were infected. The most important and predominant histopathological lesion in infected animals were epitheloid granulomas presented in the liver, spleen, adrenal gland and lung of some animals. Channels containing erythrocytes in some granulomas of the liver suggeste that these granulomas are formed inside sinusoidal capillaries. Despite the animals were proved to be infected and presented characteristic histologic lesions, they did not present external signs of disease. The granulomatous aspect of the lesions indicates a good immunologic reactivity and suggest that a host-parasite equilibrium does exist in the dog experimental model |
| first_indexed | 2024-03-12T18:10:46Z |
| format | Article |
| id | doaj.art-ee224d0bcaa342dfb27653ad951e7a61 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:10:46Z |
| publishDate | 1993-06-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-ee224d0bcaa342dfb27653ad951e7a612023-08-02T09:16:22ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601993-06-0188224324810.1590/S0074-02761993000200011The subclinical form of experimental visceral leishmaniasis in dogsG. G. S. OliveiraF. SantoroM. SadigurskyPathological aspects of a subclinical form of experimental canine leishmaniasis is reported here for the first time. Fifteen mongrel dogs were used in the present study. Eight dogs were infected and seven were used as control. Four of the control dogs were inoculated with spleen cells from non-infected hamsters. The eight mongrel dogs inoculated intravenously with amastigotes forms of Leishmania chagasi envolved for periods as long as 25 months without any clinical characteristic sign of classical Visceral Leishmaniasis (VL). Most of the laboratory test results were compatible to those of the seven control animals but culture of bone marrow aspirated material and serologic testing (IIF) demonstrated or provided evidence that the animals were infected. The most important and predominant histopathological lesion in infected animals were epitheloid granulomas presented in the liver, spleen, adrenal gland and lung of some animals. Channels containing erythrocytes in some granulomas of the liver suggeste that these granulomas are formed inside sinusoidal capillaries. Despite the animals were proved to be infected and presented characteristic histologic lesions, they did not present external signs of disease. The granulomatous aspect of the lesions indicates a good immunologic reactivity and suggest that a host-parasite equilibrium does exist in the dog experimental modelhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000200011Leishmania chagasicanine leishmaniasissubclinical formhistopathology |
| spellingShingle | G. G. S. Oliveira F. Santoro M. Sadigursky The subclinical form of experimental visceral leishmaniasis in dogs Memorias do Instituto Oswaldo Cruz Leishmania chagasi canine leishmaniasis subclinical form histopathology |
| title | The subclinical form of experimental visceral leishmaniasis in dogs |
| title_full | The subclinical form of experimental visceral leishmaniasis in dogs |
| title_fullStr | The subclinical form of experimental visceral leishmaniasis in dogs |
| title_full_unstemmed | The subclinical form of experimental visceral leishmaniasis in dogs |
| title_short | The subclinical form of experimental visceral leishmaniasis in dogs |
| title_sort | subclinical form of experimental visceral leishmaniasis in dogs |
| topic | Leishmania chagasi canine leishmaniasis subclinical form histopathology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000200011 |
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