Pak1ip1 Loss-of-Function Leads to Cell Cycle Arrest, Loss of Neural Crest Cells, and Craniofacial Abnormalities

Pak1ip1 Loss-of-Function Leads to Cell Cycle Arrest, Loss of Neural Crest Cells, and Craniofacial Abnormalities

Neural crest cells (NCCs) comprise a transient progenitor cell population of neuroepithelial origin that contributes to a variety of cell types throughout vertebrate embryos including most mesenchymal cells of the cranial and facial structures. Consequently, abnormal NCC development underlies a vari...

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Bibliographic Details
Main Authors: Alexios A. Panoutsopoulos, Angelo Harlan De Crescenzo, Albert Lee, Amelia MacKenzie Lu, Adam P. Ross, Laura N. Borodinsky, Ralph Marcucio, Paul A. Trainor, Konstantinos S. Zarbalis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
neural crest
development
orofacial clefts
mouse
Pak1ip1
ribosomopathies
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.510063/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.510063/full

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