Kidney Transplantation from АВ0-Incompatible Living Family Donor
The introduction into the clinical practice of kidney transplantation from АВ0-incompatible living donor may be one of the ways to solve the problem of shortage of cadaveric donor organs. The objective of this study was to analyze the first 4 such surgeries performed at the National Institute of Sur...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2015-10-01
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| Series: | Počki |
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| Online Access: | http://kidneys.zaslavsky.com.ua/article/view/74894 |
| _version_ | 1819281792680591360 |
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| author | R.O. Zohrabian |
| author_facet | R.O. Zohrabian |
| author_sort | R.O. Zohrabian |
| collection | DOAJ |
| description | The introduction into the clinical practice of kidney transplantation from АВ0-incompatible living donor may be one of the ways to solve the problem of shortage of cadaveric donor organs. The objective of this study was to analyze the first 4 such surgeries performed at the National Institute of Surgery and Transplantology named after O.O. Shalimov of National Academy of Medical Sciences of Ukraine. Special pretransplantation preparation of patients included introduction of rituximab, intravenous immunoglobulin, sessions of specific immune adsorption to remove anti-A/B antibodies and administration of immunosuppressants 2 weeks prior to surgery. Subsequently, recipients received a traditional 4-component immunosuppressive therapy (+ basiliximab), which differed from the usual one only by slightly larger doses of tacrolimus. In all cases, we observed satisfactory restoration of the function of the kidney transplant. The crises of acute kidney rejection were not detected. Two patients had episodes of acute pyelonephritis treated with antibiotics. Follow-up period ranged from 5 to 18 months. The survival rate of recipients and transplants currently is 100 %. Conclusion: АВ0-incompatible kidney transplantation from a living family donor is a promising direction of transplantology, whose development in Ukraine may to some extent solve the problem of acute shortage of cadaveric donor organs. |
| first_indexed | 2024-12-24T01:05:19Z |
| format | Article |
| id | doaj.art-ee2412cd069745bfb43e5b98364461be |
| institution | Directory Open Access Journal |
| issn | 2307-1257 2307-1265 |
| language | English |
| last_indexed | 2024-12-24T01:05:19Z |
| publishDate | 2015-10-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Počki |
| spelling | doaj.art-ee2412cd069745bfb43e5b98364461be2022-12-21T17:23:15ZengZaslavsky O.Yu.Počki2307-12572307-12652015-10-0154.14454910.22141/2307-1257.0.4.14.2015.7489474894Kidney Transplantation from АВ0-Incompatible Living Family DonorR.O. Zohrabian0State Institution «National Institute of Surgery and Transplantology named after O.O. Shalimov» of National Academy of Medical Sciences of Ukraine, Kyiv, UkraineThe introduction into the clinical practice of kidney transplantation from АВ0-incompatible living donor may be one of the ways to solve the problem of shortage of cadaveric donor organs. The objective of this study was to analyze the first 4 such surgeries performed at the National Institute of Surgery and Transplantology named after O.O. Shalimov of National Academy of Medical Sciences of Ukraine. Special pretransplantation preparation of patients included introduction of rituximab, intravenous immunoglobulin, sessions of specific immune adsorption to remove anti-A/B antibodies and administration of immunosuppressants 2 weeks prior to surgery. Subsequently, recipients received a traditional 4-component immunosuppressive therapy (+ basiliximab), which differed from the usual one only by slightly larger doses of tacrolimus. In all cases, we observed satisfactory restoration of the function of the kidney transplant. The crises of acute kidney rejection were not detected. Two patients had episodes of acute pyelonephritis treated with antibiotics. Follow-up period ranged from 5 to 18 months. The survival rate of recipients and transplants currently is 100 %. Conclusion: АВ0-incompatible kidney transplantation from a living family donor is a promising direction of transplantology, whose development in Ukraine may to some extent solve the problem of acute shortage of cadaveric donor organs.http://kidneys.zaslavsky.com.ua/article/view/74894kidney transplantationblood group incompatibility |
| spellingShingle | R.O. Zohrabian Kidney Transplantation from АВ0-Incompatible Living Family Donor Počki kidney transplantation blood group incompatibility |
| title | Kidney Transplantation from АВ0-Incompatible Living Family Donor |
| title_full | Kidney Transplantation from АВ0-Incompatible Living Family Donor |
| title_fullStr | Kidney Transplantation from АВ0-Incompatible Living Family Donor |
| title_full_unstemmed | Kidney Transplantation from АВ0-Incompatible Living Family Donor |
| title_short | Kidney Transplantation from АВ0-Incompatible Living Family Donor |
| title_sort | kidney transplantation from ав0 incompatible living family donor |
| topic | kidney transplantation blood group incompatibility |
| url | http://kidneys.zaslavsky.com.ua/article/view/74894 |
| work_keys_str_mv | AT rozohrabian kidneytransplantationfromav0incompatiblelivingfamilydonor |