Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes Mellitus
BackgroundMetabolic syndrome (MetS) is a known predictor of diabetes mellitus (DM), but whether longitudinal changes in MetS status modify the risk for DM remains unclear. We investigated whether changes in MetS status over 2 years modify the 10-year risk of incident DM.MethodsWe analyzed data from...
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2019-08-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/upload/pdf/dmj-43-530.pdf |
| _version_ | 1818531867336376320 |
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| author | Ji Hye Huh Sung Gyun Ahn Young In Kim Taehwa Go Ki-Chul Sung Jae Hyuk Choi Kwang Kon Koh Jang Young Kim |
| author_facet | Ji Hye Huh Sung Gyun Ahn Young In Kim Taehwa Go Ki-Chul Sung Jae Hyuk Choi Kwang Kon Koh Jang Young Kim |
| author_sort | Ji Hye Huh |
| collection | DOAJ |
| description | BackgroundMetabolic syndrome (MetS) is a known predictor of diabetes mellitus (DM), but whether longitudinal changes in MetS status modify the risk for DM remains unclear. We investigated whether changes in MetS status over 2 years modify the 10-year risk of incident DM.MethodsWe analyzed data from 7,317 participants aged 40 to 70 years without DM at baseline, who took part in 2001 to 2011 Korean Genome Epidemiology Study. Subjects were categorized into four groups based on repeated longitudinal assessment of MetS status over 2 years: non-MetS, resolved MetS, incident MetS, and persistent MetS. The hazard ratio (HR) of new-onset DM during 10 years was calculated in each group using Cox models.ResultsDuring the 10-year follow-up, 1,099 participants (15.0%) developed DM. Compared to the non-MetS group, the fully adjusted HRs for new-onset DM were 1.28 (95% confidence interval [CI], 0.92 to 1.79) in the resolved MetS group, 1.75 (95% CI, 1.30 to 2.37) in the incident MetS group, and 1.98 (95% CI, 1.50 to 2.61) in the persistent MetS group (P for trend <0.001). The risk of DM in subjects with resolved MetS was significantly attenuated compared to those with persistent MetS over 2 years. In addition, the adjusted HR for 10-year developing DM gradually increased as the number of MetS components increased 2 years later.ConclusionWe found that discrete longitudinal changes pattern in MetS status over 2 years associated with 10-year risk of DM. These findings suggest that monitoring change of MetS status and controlling it in individuals may be important for risk prediction of DM. |
| first_indexed | 2024-12-11T17:38:03Z |
| format | Article |
| id | doaj.art-ee24ca580988432abc467222bb2a2bbb |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-11T17:38:03Z |
| publishDate | 2019-08-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-ee24ca580988432abc467222bb2a2bbb2022-12-22T00:56:37ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872019-08-0143453053810.4093/dmj.2018.0111652Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes MellitusJi Hye Huh0Sung Gyun Ahn1Young In Kim2Taehwa Go3Ki-Chul Sung4Jae Hyuk Choi5Kwang Kon Koh6Jang Young Kim7Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, .KoreaDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, .KoreaDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, .KoreaCenter of Biomedical Data Science, Yonsei University Wonju College of Medicine, Wonju, .KoreaDivision of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, .KoreaDivision of Cardiology, Department of Internal Medicine, Hallym University Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, .KoreaDivision of Cardiology, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, .KoreaDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, .KoreaBackgroundMetabolic syndrome (MetS) is a known predictor of diabetes mellitus (DM), but whether longitudinal changes in MetS status modify the risk for DM remains unclear. We investigated whether changes in MetS status over 2 years modify the 10-year risk of incident DM.MethodsWe analyzed data from 7,317 participants aged 40 to 70 years without DM at baseline, who took part in 2001 to 2011 Korean Genome Epidemiology Study. Subjects were categorized into four groups based on repeated longitudinal assessment of MetS status over 2 years: non-MetS, resolved MetS, incident MetS, and persistent MetS. The hazard ratio (HR) of new-onset DM during 10 years was calculated in each group using Cox models.ResultsDuring the 10-year follow-up, 1,099 participants (15.0%) developed DM. Compared to the non-MetS group, the fully adjusted HRs for new-onset DM were 1.28 (95% confidence interval [CI], 0.92 to 1.79) in the resolved MetS group, 1.75 (95% CI, 1.30 to 2.37) in the incident MetS group, and 1.98 (95% CI, 1.50 to 2.61) in the persistent MetS group (P for trend <0.001). The risk of DM in subjects with resolved MetS was significantly attenuated compared to those with persistent MetS over 2 years. In addition, the adjusted HR for 10-year developing DM gradually increased as the number of MetS components increased 2 years later.ConclusionWe found that discrete longitudinal changes pattern in MetS status over 2 years associated with 10-year risk of DM. These findings suggest that monitoring change of MetS status and controlling it in individuals may be important for risk prediction of DM.http://e-dmj.org/upload/pdf/dmj-43-530.pdfdiabetes mellituslife stylemetabolic syndrome |
| spellingShingle | Ji Hye Huh Sung Gyun Ahn Young In Kim Taehwa Go Ki-Chul Sung Jae Hyuk Choi Kwang Kon Koh Jang Young Kim Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes Mellitus Diabetes & Metabolism Journal diabetes mellitus life style metabolic syndrome |
| title | Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes Mellitus |
| title_full | Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes Mellitus |
| title_fullStr | Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes Mellitus |
| title_full_unstemmed | Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes Mellitus |
| title_short | Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes Mellitus |
| title_sort | impact of longitudinal changes in metabolic syndrome status over 2 years on 10 year incident diabetes mellitus |
| topic | diabetes mellitus life style metabolic syndrome |
| url | http://e-dmj.org/upload/pdf/dmj-43-530.pdf |
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