Urinary liver-type fatty acid-binding protein is associated with subendocardial viability ratio in middle- and older-aged adults
Background: To identify one of the physiological underlying mechanisms of the predictive effects of urinary liver-type fatty acid-binding protein (L-FABP) for the onset of cardiovascular disease (CVD), we investigated the relationship between urinary L-FABP levels and subendocardial viability ratio...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-04-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | http://dx.doi.org/10.1080/10641963.2017.1356845 |
| _version_ | 1827814290551209984 |
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| author | Keisei Kosaki Atsuko Kamijo-Ikemori Takeshi Sugaya Koichiro Tanahashi Hiroshi Kumagai Yuriko Sawano Nobuhiko Akazawa Yosuke Osuka Kiyoji Tanaka Kenjiro Kimura Yugo Shibagaki Seiji Maeda |
| author_facet | Keisei Kosaki Atsuko Kamijo-Ikemori Takeshi Sugaya Koichiro Tanahashi Hiroshi Kumagai Yuriko Sawano Nobuhiko Akazawa Yosuke Osuka Kiyoji Tanaka Kenjiro Kimura Yugo Shibagaki Seiji Maeda |
| author_sort | Keisei Kosaki |
| collection | DOAJ |
| description | Background: To identify one of the physiological underlying mechanisms of the predictive effects of urinary liver-type fatty acid-binding protein (L-FABP) for the onset of cardiovascular disease (CVD), we investigated the relationship between urinary L-FABP levels and subendocardial viability ratio (SEVR), a marker of myocardial perfusion, in middle- and older-aged adults. Methods: This was a cross-sectional study of 249 middle- and older-aged adults (aged 46–83 years). We measured urinary L-FABP levels and central hemodynamic parameters, including SEVR, calculated by pulse wave analysis using an applanation tonometry. Results: In the participants stratified in accordance with the tertiles of urinary L-FABP levels, SEVR decreased in a stepwise fashion with increasing tertiles (p < 0.001). Furthermore, this association remains significant after the consideration of various confounders. On the contrary, urinary albumin levels were not independently related with SEVR. Conclusion: Our results demonstrated that urinary L-FABP levels were independently associated with the SEVR of the middle- and older-aged adults. This result suggests that the increase in urinary L-FABP levels even within the normal range might be related to the decrease in myocardial perfusion (SEVR). |
| first_indexed | 2024-03-11T23:44:29Z |
| format | Article |
| id | doaj.art-ee254bc2592a4f85a64106833d5ef242 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:44:29Z |
| publishDate | 2018-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-ee254bc2592a4f85a64106833d5ef2422023-09-19T15:19:26ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062018-04-0140324425010.1080/10641963.2017.13568451356845Urinary liver-type fatty acid-binding protein is associated with subendocardial viability ratio in middle- and older-aged adultsKeisei Kosaki0Atsuko Kamijo-Ikemori1Takeshi Sugaya2Koichiro Tanahashi3Hiroshi Kumagai4Yuriko Sawano5Nobuhiko Akazawa6Yosuke Osuka7Kiyoji Tanaka8Kenjiro Kimura9Yugo Shibagaki10Seiji Maeda11University of TsukubaSt. Marianna University School of MedicineSt. Marianna University School of MedicineUniversity of TsukubaUniversity of TsukubaUniversity of TsukubaUniversity of TsukubaTokyo Metropolitan Institute of GerontologyUniversity of TsukubaJCHO Tokyo Takanawa HospitalSt. Marianna University School of MedicineUniversity of TsukubaBackground: To identify one of the physiological underlying mechanisms of the predictive effects of urinary liver-type fatty acid-binding protein (L-FABP) for the onset of cardiovascular disease (CVD), we investigated the relationship between urinary L-FABP levels and subendocardial viability ratio (SEVR), a marker of myocardial perfusion, in middle- and older-aged adults. Methods: This was a cross-sectional study of 249 middle- and older-aged adults (aged 46–83 years). We measured urinary L-FABP levels and central hemodynamic parameters, including SEVR, calculated by pulse wave analysis using an applanation tonometry. Results: In the participants stratified in accordance with the tertiles of urinary L-FABP levels, SEVR decreased in a stepwise fashion with increasing tertiles (p < 0.001). Furthermore, this association remains significant after the consideration of various confounders. On the contrary, urinary albumin levels were not independently related with SEVR. Conclusion: Our results demonstrated that urinary L-FABP levels were independently associated with the SEVR of the middle- and older-aged adults. This result suggests that the increase in urinary L-FABP levels even within the normal range might be related to the decrease in myocardial perfusion (SEVR).http://dx.doi.org/10.1080/10641963.2017.1356845cardiovascular diseaseintra-renal microcirculationmyocardial perfusionpulse wave analysistubular biomarker |
| spellingShingle | Keisei Kosaki Atsuko Kamijo-Ikemori Takeshi Sugaya Koichiro Tanahashi Hiroshi Kumagai Yuriko Sawano Nobuhiko Akazawa Yosuke Osuka Kiyoji Tanaka Kenjiro Kimura Yugo Shibagaki Seiji Maeda Urinary liver-type fatty acid-binding protein is associated with subendocardial viability ratio in middle- and older-aged adults Clinical and Experimental Hypertension cardiovascular disease intra-renal microcirculation myocardial perfusion pulse wave analysis tubular biomarker |
| title | Urinary liver-type fatty acid-binding protein is associated with subendocardial viability ratio in middle- and older-aged adults |
| title_full | Urinary liver-type fatty acid-binding protein is associated with subendocardial viability ratio in middle- and older-aged adults |
| title_fullStr | Urinary liver-type fatty acid-binding protein is associated with subendocardial viability ratio in middle- and older-aged adults |
| title_full_unstemmed | Urinary liver-type fatty acid-binding protein is associated with subendocardial viability ratio in middle- and older-aged adults |
| title_short | Urinary liver-type fatty acid-binding protein is associated with subendocardial viability ratio in middle- and older-aged adults |
| title_sort | urinary liver type fatty acid binding protein is associated with subendocardial viability ratio in middle and older aged adults |
| topic | cardiovascular disease intra-renal microcirculation myocardial perfusion pulse wave analysis tubular biomarker |
| url | http://dx.doi.org/10.1080/10641963.2017.1356845 |
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