Selective activation of striatal indirect pathway suppresses levodopa induced-dyskinesias

Selective activation of striatal indirect pathway suppresses levodopa induced-dyskinesias

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Levodopa (L-DOPA) administration remains the gold standard therapy for Parkinson's disease (PD). Despite several pharmacological advances in the use of L-DOPA, a high proportion of chronically treated patients continues to suffer disabling involuntary movements, namely, L-DOPA-induced dyskinesi...

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Bibliographic Details
Main Authors: Iván Castela, Raquel Casado-Polanco, Yaiza Van-Waes Rubio, Joaquim Alves da Silva, Raquel Marquez, Beatriz Pro, Rosario Moratalla, Peter Redgrave, Rui M. Costa, José Obeso, Ledia F. Hernandez
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Dyskinesia
LIDs
Striatum
Optogenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122003229

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