Gut Microbiota Host–Gene Interaction
Studies carried out in the last ten years have shown that the metabolites made up from the gut microbiota are essential for multiple functions, such as the correct development of the immune system of newborns, interception of pathogens, and nutritional enrichment of the diet. Therefore, it is not su...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/22/13717 |
| _version_ | 1797465204006584320 |
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| author | Paola Cuomo Rosanna Capparelli Marco Alifano Antonio Iannelli Domenico Iannelli |
| author_facet | Paola Cuomo Rosanna Capparelli Marco Alifano Antonio Iannelli Domenico Iannelli |
| author_sort | Paola Cuomo |
| collection | DOAJ |
| description | Studies carried out in the last ten years have shown that the metabolites made up from the gut microbiota are essential for multiple functions, such as the correct development of the immune system of newborns, interception of pathogens, and nutritional enrichment of the diet. Therefore, it is not surprising that alteration of the gut microbiota is the starting point of gastrointestinal infection, obesity, type 2 diabetes, inflammatory bowel disease, colorectal cancer, and lung cancer. Diet changes and antibiotics are the major factors damaging the gut microbiota. Early exposure of the newborns to antibiotics may prevent their correct development of the immune system, exposing them to pathogen infections, allergies, and chronic inflammatory diseases. We already know much on how host genes, microbiota, and the environment interact, owing to experiments in several model animals, especially in mice; advances in molecular technology; microbiota transplantation; and comparative metagenomic analysis. However, much more remains to be known. Longitudinal studies on patients undergoing to therapy, along with the identification of bacteria prevalent in responding patients may provide valuable data for improving therapies. |
| first_indexed | 2024-03-09T18:19:08Z |
| format | Article |
| id | doaj.art-ee2998a070d041ba9a534c053cbfabc6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:19:08Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ee2998a070d041ba9a534c053cbfabc62023-11-24T08:32:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221371710.3390/ijms232213717Gut Microbiota Host–Gene InteractionPaola Cuomo0Rosanna Capparelli1Marco Alifano2Antonio Iannelli3Domenico Iannelli4Department of Agriculture Sciences, University of Naples “Federico II”, Via Università 100, Portici, 80055 Naples, ItalyDepartment of Agriculture Sciences, University of Naples “Federico II”, Via Università 100, Portici, 80055 Naples, ItalyThoracic Surgery Department, Cochin Hospital, APHP Centre, University of Paris, 75014 Paris, FranceCentre Hospitalier Universitaire de Nice—Digestive Surgery and Liver Transplantation Unit, Archet 2 Hospital, 06202 Nice, FranceDepartment of Agriculture Sciences, University of Naples “Federico II”, Via Università 100, Portici, 80055 Naples, ItalyStudies carried out in the last ten years have shown that the metabolites made up from the gut microbiota are essential for multiple functions, such as the correct development of the immune system of newborns, interception of pathogens, and nutritional enrichment of the diet. Therefore, it is not surprising that alteration of the gut microbiota is the starting point of gastrointestinal infection, obesity, type 2 diabetes, inflammatory bowel disease, colorectal cancer, and lung cancer. Diet changes and antibiotics are the major factors damaging the gut microbiota. Early exposure of the newborns to antibiotics may prevent their correct development of the immune system, exposing them to pathogen infections, allergies, and chronic inflammatory diseases. We already know much on how host genes, microbiota, and the environment interact, owing to experiments in several model animals, especially in mice; advances in molecular technology; microbiota transplantation; and comparative metagenomic analysis. However, much more remains to be known. Longitudinal studies on patients undergoing to therapy, along with the identification of bacteria prevalent in responding patients may provide valuable data for improving therapies.https://www.mdpi.com/1422-0067/23/22/13717gut microbiotagut cancerlung cancer<i>Helicobacter pylori</i>inflammatory bowel disease |
| spellingShingle | Paola Cuomo Rosanna Capparelli Marco Alifano Antonio Iannelli Domenico Iannelli Gut Microbiota Host–Gene Interaction International Journal of Molecular Sciences gut microbiota gut cancer lung cancer <i>Helicobacter pylori</i> inflammatory bowel disease |
| title | Gut Microbiota Host–Gene Interaction |
| title_full | Gut Microbiota Host–Gene Interaction |
| title_fullStr | Gut Microbiota Host–Gene Interaction |
| title_full_unstemmed | Gut Microbiota Host–Gene Interaction |
| title_short | Gut Microbiota Host–Gene Interaction |
| title_sort | gut microbiota host gene interaction |
| topic | gut microbiota gut cancer lung cancer <i>Helicobacter pylori</i> inflammatory bowel disease |
| url | https://www.mdpi.com/1422-0067/23/22/13717 |
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