Biological Activities of Secretory RNases: Focus on Their Oligomerization to Design Antitumor Drugs

Biological Activities of Secretory RNases: Focus on Their Oligomerization to Design Antitumor Drugs

Ribonucleases (RNases) are a large number of enzymes gathered into different bacterial or eukaryotic superfamilies. Bovine pancreatic RNase A, bovine seminal BS-RNase, human pancreatic RNase 1, angiogenin (RNase 5), and amphibian onconase belong to the pancreatic type superfamily, while binase and b...

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Bibliographic Details
Main Authors: Giovanni Gotte, Marta Menegazzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
ribonucleases
RNase oligomers
domain swapping
cytotoxicity
antitumor activity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02626/full

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