Transcranial direct current stimulation modulates brain functional connectivity in autism
Autism spectrum disorder (ASD) is characterized by deficits in social interactions, impairments in language and communication, and highly restricted behavioral interests. Transcranial direct current stimulation (tDCS) is a widely used form of noninvasive stimulation and may have therapeutic potentia...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158220303375 |
| _version_ | 1819060352985333760 |
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| author | Tianyi Zhou Jiannan Kang Zheng Li He Chen Xiaoli Li |
| author_facet | Tianyi Zhou Jiannan Kang Zheng Li He Chen Xiaoli Li |
| author_sort | Tianyi Zhou |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is characterized by deficits in social interactions, impairments in language and communication, and highly restricted behavioral interests. Transcranial direct current stimulation (tDCS) is a widely used form of noninvasive stimulation and may have therapeutic potential for ASD. So far, despite the widespread use of this technique in the neuroscience field, its effects on network-level neural activity and the underlying mechanisms of any effects are still unclear. In the present study, we used electroencephalography (EEG) to investigate tDCS induced brain network changes in children with ASD before and after active and sham stimulation. We recorded 5 min of resting state EEG before and after a single session of tDCS (of approximately 20 min) over dorsolateral prefrontal cortex (DLPFC). Two network-based methods were applied to investigate tDCS modulation on brain networks: 1) temporal network dynamics were analyzed by comparing “flexibility” changes before vs after stimulation, and 2) frequency specific network changes were identified using non-negative matrix factorization (NMF). We found 1) an increase in network flexibility following tDCS (rapid network configuration of dynamic network communities), 2) specific increase in interhemispheric connectivity within the alpha frequency band following tDCS. Together, these results demonstrate that tDCS could help modify both local and global brain network dynamics, and highlight stimulation-induced differences in the manifestation of network reconfiguration. Meanwhile, frequency–specific subnetworks, as a way to index local and global information processing, highlight the core modulatory effects of tDCS on the modular architecture of the functional connectivity patterns within higher frequency bands. |
| first_indexed | 2024-12-21T14:25:38Z |
| format | Article |
| id | doaj.art-ee2e599d087242e19efc41f89105d5ee |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-21T14:25:38Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-ee2e599d087242e19efc41f89105d5ee2022-12-21T19:00:40ZengElsevierNeuroImage: Clinical2213-15822020-01-0128102500Transcranial direct current stimulation modulates brain functional connectivity in autismTianyi Zhou0Jiannan Kang1Zheng Li2He Chen3Xiaoli Li4Center for Cognition and Neuroergonomics, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Zhuhai 519087, ChinaCollege of Electronic & Information Engineering, Hebei University, Baoding, ChinaCenter for Cognition and Neuroergonomics, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Zhuhai 519087, ChinaState Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, ChinaState Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China; Corresponding author.Autism spectrum disorder (ASD) is characterized by deficits in social interactions, impairments in language and communication, and highly restricted behavioral interests. Transcranial direct current stimulation (tDCS) is a widely used form of noninvasive stimulation and may have therapeutic potential for ASD. So far, despite the widespread use of this technique in the neuroscience field, its effects on network-level neural activity and the underlying mechanisms of any effects are still unclear. In the present study, we used electroencephalography (EEG) to investigate tDCS induced brain network changes in children with ASD before and after active and sham stimulation. We recorded 5 min of resting state EEG before and after a single session of tDCS (of approximately 20 min) over dorsolateral prefrontal cortex (DLPFC). Two network-based methods were applied to investigate tDCS modulation on brain networks: 1) temporal network dynamics were analyzed by comparing “flexibility” changes before vs after stimulation, and 2) frequency specific network changes were identified using non-negative matrix factorization (NMF). We found 1) an increase in network flexibility following tDCS (rapid network configuration of dynamic network communities), 2) specific increase in interhemispheric connectivity within the alpha frequency band following tDCS. Together, these results demonstrate that tDCS could help modify both local and global brain network dynamics, and highlight stimulation-induced differences in the manifestation of network reconfiguration. Meanwhile, frequency–specific subnetworks, as a way to index local and global information processing, highlight the core modulatory effects of tDCS on the modular architecture of the functional connectivity patterns within higher frequency bands.http://www.sciencedirect.com/science/article/pii/S2213158220303375Autism spectrum disorderTranscranial direct current stimulationNetwork-based approachesBrain plasticityFrequency-dependent subnetworks |
| spellingShingle | Tianyi Zhou Jiannan Kang Zheng Li He Chen Xiaoli Li Transcranial direct current stimulation modulates brain functional connectivity in autism NeuroImage: Clinical Autism spectrum disorder Transcranial direct current stimulation Network-based approaches Brain plasticity Frequency-dependent subnetworks |
| title | Transcranial direct current stimulation modulates brain functional connectivity in autism |
| title_full | Transcranial direct current stimulation modulates brain functional connectivity in autism |
| title_fullStr | Transcranial direct current stimulation modulates brain functional connectivity in autism |
| title_full_unstemmed | Transcranial direct current stimulation modulates brain functional connectivity in autism |
| title_short | Transcranial direct current stimulation modulates brain functional connectivity in autism |
| title_sort | transcranial direct current stimulation modulates brain functional connectivity in autism |
| topic | Autism spectrum disorder Transcranial direct current stimulation Network-based approaches Brain plasticity Frequency-dependent subnetworks |
| url | http://www.sciencedirect.com/science/article/pii/S2213158220303375 |
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