Seeking the “mother of blood” from human pluripotent stem cells: Are we there yet?
Induced pluripotent stem cells (iPSCs) hold great promise for the treatment of human diseases, including the failure of bone marrow. Incremental progress across the past three and half decades has brought us closer to making hematopoietic stem cells from iPSCs clinical solutions. A recent innovative...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2017-09-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304217300442 |
| _version_ | 1827267053668532224 |
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| author | Fei Li |
| author_facet | Fei Li |
| author_sort | Fei Li |
| collection | DOAJ |
| description | Induced pluripotent stem cells (iPSCs) hold great promise for the treatment of human diseases, including the failure of bone marrow. Incremental progress across the past three and half decades has brought us closer to making hematopoietic stem cells from iPSCs clinical solutions. A recent innovative two-step differentiation approach successfully generated transplantable HSCs from iPSC sources. For clinical translation, the long-term safety of these gene-altered HSCs must be determined. |
| first_indexed | 2024-03-12T06:01:16Z |
| format | Article |
| id | doaj.art-ee2e7efaf9f8491a9ce96f71c5d28f6b |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2025-03-22T04:27:38Z |
| publishDate | 2017-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-ee2e7efaf9f8491a9ce96f71c5d28f6b2024-04-28T05:29:28ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422017-09-014312312410.1016/j.gendis.2017.07.005Seeking the “mother of blood” from human pluripotent stem cells: Are we there yet?Fei LiInduced pluripotent stem cells (iPSCs) hold great promise for the treatment of human diseases, including the failure of bone marrow. Incremental progress across the past three and half decades has brought us closer to making hematopoietic stem cells from iPSCs clinical solutions. A recent innovative two-step differentiation approach successfully generated transplantable HSCs from iPSC sources. For clinical translation, the long-term safety of these gene-altered HSCs must be determined.http://www.sciencedirect.com/science/article/pii/S2352304217300442Hemaotpoietic stem cellsHuman iPSCLentiviral transductionTeratomaTranscription factorsXeno-transplantation |
| spellingShingle | Fei Li Seeking the “mother of blood” from human pluripotent stem cells: Are we there yet? Genes and Diseases Hemaotpoietic stem cells Human iPSC Lentiviral transduction Teratoma Transcription factors Xeno-transplantation |
| title | Seeking the “mother of blood” from human pluripotent stem cells: Are we there yet? |
| title_full | Seeking the “mother of blood” from human pluripotent stem cells: Are we there yet? |
| title_fullStr | Seeking the “mother of blood” from human pluripotent stem cells: Are we there yet? |
| title_full_unstemmed | Seeking the “mother of blood” from human pluripotent stem cells: Are we there yet? |
| title_short | Seeking the “mother of blood” from human pluripotent stem cells: Are we there yet? |
| title_sort | seeking the mother of blood from human pluripotent stem cells are we there yet |
| topic | Hemaotpoietic stem cells Human iPSC Lentiviral transduction Teratoma Transcription factors Xeno-transplantation |
| url | http://www.sciencedirect.com/science/article/pii/S2352304217300442 |
| work_keys_str_mv | AT feili seekingthemotherofbloodfromhumanpluripotentstemcellsarewethereyet |