Targeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy

Targeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy

ABSTRACTAntibody-cytokine fusions targeted against tumor-associated antigens (TAAs) are promising cancer immunotherapy agents, with many such molecules currently undergoing clinical trials. However, due to the limited number of tumor-specific targets, on-target off-tumor effects can lead to systemic...

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Bibliographic Details
Main Authors: Vedran Vasic, Can Buldun, Manfred Ritz, Steffen Dickopf, Guy J. Georges, Christian Spick, Alessa Peuker, Thomas Meier, Klaus Mayer, Ulrich Brinkmann
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
antibody engineering
antibody-cytokine fusions
cancer immunotherapy
conditional activation
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2245111

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