Oral administration of Lactobacillus delbrueckii during the suckling period improves intestinal integrity after weaning in piglets
This study was conducted to explore the effect of administrated Lactobacillus delbrueckii (LAB) during the suckling period on future intestinal integrity of the host, using a piglet model. Probiotic LAB increased final body weight, concentrations of immunoglobulin G and anti-inflammatory cytokines,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619305158 |
| _version_ | 1818563103943557120 |
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| author | Yinghui Li Shuling Hou Jiashun Chen Wei Peng Wei Wen Fengming Chen Xingguo Huang |
| author_facet | Yinghui Li Shuling Hou Jiashun Chen Wei Peng Wei Wen Fengming Chen Xingguo Huang |
| author_sort | Yinghui Li |
| collection | DOAJ |
| description | This study was conducted to explore the effect of administrated Lactobacillus delbrueckii (LAB) during the suckling period on future intestinal integrity of the host, using a piglet model. Probiotic LAB increased final body weight, concentrations of immunoglobulin G and anti-inflammatory cytokines, but reduced diarrhea incidence by over 50% during any phase of experimental period. The intestinal villus height of the LAB-treated piglets were greater than that in the control piglets. Along with lower activity of serum diamine oxidase in the LAB piglets, there was a concurrent increase in mRNA expression of intestinal tight junctions proteins. We conclude that LAB, given to suckling piglets, stimulates immune response and improves intestinal morphology and barrier function, thereby mitigating diarrhea and promoting growth, importantly, these beneficial effects could be maintained up to 4 weeks after weaning. A proper utilization of LAB to neonates would be beneficial to future intestinal health. |
| first_indexed | 2024-12-14T01:12:27Z |
| format | Article |
| id | doaj.art-ee329dc37b0c41efb49e0976012e18c8 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T01:12:27Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-ee329dc37b0c41efb49e0976012e18c82022-12-21T23:22:41ZengElsevierJournal of Functional Foods1756-46462019-12-0163Oral administration of Lactobacillus delbrueckii during the suckling period improves intestinal integrity after weaning in pigletsYinghui Li0Shuling Hou1Jiashun Chen2Wei Peng3Wei Wen4Fengming Chen5Xingguo Huang6College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Co-Innovation Center of Animal Production Safety, CICAPS, Changsha, Hunan 410128, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Co-Innovation Center of Animal Production Safety, CICAPS, Changsha, Hunan 410128, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Co-Innovation Center of Animal Production Safety, CICAPS, Changsha, Hunan 410128, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Co-Innovation Center of Animal Production Safety, CICAPS, Changsha, Hunan 410128, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Co-Innovation Center of Animal Production Safety, CICAPS, Changsha, Hunan 410128, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Co-Innovation Center of Animal Production Safety, CICAPS, Changsha, Hunan 410128, ChinaCorresponding author at: College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China.; College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Co-Innovation Center of Animal Production Safety, CICAPS, Changsha, Hunan 410128, ChinaThis study was conducted to explore the effect of administrated Lactobacillus delbrueckii (LAB) during the suckling period on future intestinal integrity of the host, using a piglet model. Probiotic LAB increased final body weight, concentrations of immunoglobulin G and anti-inflammatory cytokines, but reduced diarrhea incidence by over 50% during any phase of experimental period. The intestinal villus height of the LAB-treated piglets were greater than that in the control piglets. Along with lower activity of serum diamine oxidase in the LAB piglets, there was a concurrent increase in mRNA expression of intestinal tight junctions proteins. We conclude that LAB, given to suckling piglets, stimulates immune response and improves intestinal morphology and barrier function, thereby mitigating diarrhea and promoting growth, importantly, these beneficial effects could be maintained up to 4 weeks after weaning. A proper utilization of LAB to neonates would be beneficial to future intestinal health.http://www.sciencedirect.com/science/article/pii/S1756464619305158Barrier functionImmune responseIntestinal morphologyPigletProbiotics |
| spellingShingle | Yinghui Li Shuling Hou Jiashun Chen Wei Peng Wei Wen Fengming Chen Xingguo Huang Oral administration of Lactobacillus delbrueckii during the suckling period improves intestinal integrity after weaning in piglets Journal of Functional Foods Barrier function Immune response Intestinal morphology Piglet Probiotics |
| title | Oral administration of Lactobacillus delbrueckii during the suckling period improves intestinal integrity after weaning in piglets |
| title_full | Oral administration of Lactobacillus delbrueckii during the suckling period improves intestinal integrity after weaning in piglets |
| title_fullStr | Oral administration of Lactobacillus delbrueckii during the suckling period improves intestinal integrity after weaning in piglets |
| title_full_unstemmed | Oral administration of Lactobacillus delbrueckii during the suckling period improves intestinal integrity after weaning in piglets |
| title_short | Oral administration of Lactobacillus delbrueckii during the suckling period improves intestinal integrity after weaning in piglets |
| title_sort | oral administration of lactobacillus delbrueckii during the suckling period improves intestinal integrity after weaning in piglets |
| topic | Barrier function Immune response Intestinal morphology Piglet Probiotics |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619305158 |
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