Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination
Semen analysis is the corner stone of infertility evaluation as it provides information on the functional status of the seminiferous tubules, epididymis and accessory sex glands. The methods on how the human semen should be evaluated are provided by the World Health Organization, which periodically...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2014-08-01
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| Series: | International Brazilian Journal of Urology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382014000400433&lng=en&tlng=en |
| _version_ | 1818274744605081600 |
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| author | Sandro C. Esteves |
| author_facet | Sandro C. Esteves |
| author_sort | Sandro C. Esteves |
| collection | DOAJ |
| description | Semen analysis is the corner stone of infertility evaluation as it provides information on the functional status of the seminiferous tubules, epididymis and accessory sex glands. The methods on how the human semen should be evaluated are provided by the World Health Organization, which periodically releases manuals that include specific protocols and reference standards. In 2010, the WHO published new criteria for human semen characteristics that were markedly lower than those previously reported. In this review initially it is discussed the limitations of semen analysis as a surrogate measure of a man’s ability to father a pregnancy. Secondly, it is analyzed methodology issues that could explain why the newly released reference values were different from those earlier reported. Thirdly, it is speculated on the likely effects of the 2010 WHO criteria in the management of male infertility. Due to the several inherent limitations of semen analysis as a surrogate marker of male infertility, physicians should exercise caution when interpreting results. A template for semen analysis reports that incorporates the distribution of the semen characteristics of recent fathers in centiles rather than solely the minimum thresholds could aid clinicians to better understand how a given patient results compare with the reference population. Importantly, a male infertility evaluation must go far beyond a simple semen analysis, as it has to be complemented with a proper physical examination, a comprehensive history taking, and relevant endocrine, genetic, and other investigations. |
| first_indexed | 2024-12-12T22:18:44Z |
| format | Article |
| id | doaj.art-ee336cd2f0db4a29b7ba4c9d1a569b21 |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-12-12T22:18:44Z |
| publishDate | 2014-08-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-ee336cd2f0db4a29b7ba4c9d1a569b212022-12-22T00:10:01ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192014-08-0140443345310.1590/S1677-5538.IBJU.2014.04.02S1677-55382014000400433Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examinationSandro C. EstevesSemen analysis is the corner stone of infertility evaluation as it provides information on the functional status of the seminiferous tubules, epididymis and accessory sex glands. The methods on how the human semen should be evaluated are provided by the World Health Organization, which periodically releases manuals that include specific protocols and reference standards. In 2010, the WHO published new criteria for human semen characteristics that were markedly lower than those previously reported. In this review initially it is discussed the limitations of semen analysis as a surrogate measure of a man’s ability to father a pregnancy. Secondly, it is analyzed methodology issues that could explain why the newly released reference values were different from those earlier reported. Thirdly, it is speculated on the likely effects of the 2010 WHO criteria in the management of male infertility. Due to the several inherent limitations of semen analysis as a surrogate marker of male infertility, physicians should exercise caution when interpreting results. A template for semen analysis reports that incorporates the distribution of the semen characteristics of recent fathers in centiles rather than solely the minimum thresholds could aid clinicians to better understand how a given patient results compare with the reference population. Importantly, a male infertility evaluation must go far beyond a simple semen analysis, as it has to be complemented with a proper physical examination, a comprehensive history taking, and relevant endocrine, genetic, and other investigations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382014000400433&lng=en&tlng=enInfertility, MaleSemen AnalysisAndrologyDiagnosisSpermatozoaReference ValuesTherapeutics |
| spellingShingle | Sandro C. Esteves Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination International Brazilian Journal of Urology Infertility, Male Semen Analysis Andrology Diagnosis Spermatozoa Reference Values Therapeutics |
| title | Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination |
| title_full | Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination |
| title_fullStr | Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination |
| title_full_unstemmed | Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination |
| title_short | Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination |
| title_sort | clinical relevance of routine semen analysis and controversies surrounding the 2010 world health organization criteria for semen examination |
| topic | Infertility, Male Semen Analysis Andrology Diagnosis Spermatozoa Reference Values Therapeutics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382014000400433&lng=en&tlng=en |
| work_keys_str_mv | AT sandrocesteves clinicalrelevanceofroutinesemenanalysisandcontroversiessurroundingthe2010worldhealthorganizationcriteriaforsemenexamination |