Exploration of Fulvic Acid as a Co-Former in Crystal Engineering
The aim of the project was to investigate Peat-derived Fulvic acid for its propensity to form co-crystals with quercetin and curcumin and characterize it by using different analytical techniques. The formation of co-crystals generally enhances water solubility and the overall bioavailability of mole...
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MDPI AG
2022-05-01
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| author | Kattamanchi Gnananath Kolli Prabhanjan Kumar Yejella Rajendra Prasad Kalakonda Sri Nataraj Mohamad Taleuzzaman Mohammad Javed Ansari Mohd. Aamir Mirza |
| author_facet | Kattamanchi Gnananath Kolli Prabhanjan Kumar Yejella Rajendra Prasad Kalakonda Sri Nataraj Mohamad Taleuzzaman Mohammad Javed Ansari Mohd. Aamir Mirza |
| author_sort | Kattamanchi Gnananath |
| collection | DOAJ |
| description | The aim of the project was to investigate Peat-derived Fulvic acid for its propensity to form co-crystals with quercetin and curcumin and characterize it by using different analytical techniques. The formation of co-crystals generally enhances water solubility and the overall bioavailability of molecules. Co-crystals were synthesized using a 1:1 stoichiometric ratio of fulvic acid with quercetin and curcumin, respectively, using solvent crystallization techniques taking tetrahydrofuran and water in a 1:1 <i>v</i>/<i>v</i> ratio. The co-crystals were characterized by spectroscopic methods, FTIR and Differential scanning calorimetry. Further confirmation was made by morphological studies using SEM. A structural analysis was also carried out, using <sup>13</sup>C solid-state NMR analysis. The studies confirmed the formation of semi crystalline forms. Furthermore, the saturation solubility displayed the enhancement in solubility of up to 10, 5-folds for Quercetin and Curcumin, respectively. The in vitro dissolution results showed that T50% was achieved within 30 min for both the drugs. The literature supports that the nutraceutical co-crystals offer advantages, particularly in the improvement of biopharmaceutical properties and addressing the challenges of the lab and manufacturing scale process. Both the semi crystalline powders exhibited enhanced solubility and a better dissolution profile. |
| first_indexed | 2024-03-10T01:52:27Z |
| format | Article |
| id | doaj.art-ee337c2cb5f9492ea37ad4024ddb7d85 |
| institution | Directory Open Access Journal |
| issn | 2297-8739 |
| language | English |
| last_indexed | 2024-03-10T01:52:27Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Separations |
| spelling | doaj.art-ee337c2cb5f9492ea37ad4024ddb7d852023-11-23T13:04:41ZengMDPI AGSeparations2297-87392022-05-019512610.3390/separations9050126Exploration of Fulvic Acid as a Co-Former in Crystal EngineeringKattamanchi Gnananath0Kolli Prabhanjan Kumar1Yejella Rajendra Prasad2Kalakonda Sri Nataraj3Mohamad Taleuzzaman4Mohammad Javed Ansari5Mohd. Aamir Mirza6Venkateswara Ayurveda Nilayam Ltd., Dhanvantari Temple Street, Chintaluru, East Godavari 533232, IndiaDepartment of Pharmaceutical Chemistry, AU College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam 530003, IndiaDepartment of Pharmaceutical Chemistry, AU College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam 530003, IndiaDepartment of Pharmaceutical Analysis & Quality Assurance, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram 534202, IndiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Maulana Azad University, Village Bujhawar, Tehsil Luni, Jodhpur 342008, IndiaDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi ArabiaDepartment of Pharmaceutics, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, IndiaThe aim of the project was to investigate Peat-derived Fulvic acid for its propensity to form co-crystals with quercetin and curcumin and characterize it by using different analytical techniques. The formation of co-crystals generally enhances water solubility and the overall bioavailability of molecules. Co-crystals were synthesized using a 1:1 stoichiometric ratio of fulvic acid with quercetin and curcumin, respectively, using solvent crystallization techniques taking tetrahydrofuran and water in a 1:1 <i>v</i>/<i>v</i> ratio. The co-crystals were characterized by spectroscopic methods, FTIR and Differential scanning calorimetry. Further confirmation was made by morphological studies using SEM. A structural analysis was also carried out, using <sup>13</sup>C solid-state NMR analysis. The studies confirmed the formation of semi crystalline forms. Furthermore, the saturation solubility displayed the enhancement in solubility of up to 10, 5-folds for Quercetin and Curcumin, respectively. The in vitro dissolution results showed that T50% was achieved within 30 min for both the drugs. The literature supports that the nutraceutical co-crystals offer advantages, particularly in the improvement of biopharmaceutical properties and addressing the challenges of the lab and manufacturing scale process. Both the semi crystalline powders exhibited enhanced solubility and a better dissolution profile.https://www.mdpi.com/2297-8739/9/5/126nutraceutical co-crystalscurcuminquercetinsemi crystallineSNMR |
| spellingShingle | Kattamanchi Gnananath Kolli Prabhanjan Kumar Yejella Rajendra Prasad Kalakonda Sri Nataraj Mohamad Taleuzzaman Mohammad Javed Ansari Mohd. Aamir Mirza Exploration of Fulvic Acid as a Co-Former in Crystal Engineering Separations nutraceutical co-crystals curcumin quercetin semi crystalline SNMR |
| title | Exploration of Fulvic Acid as a Co-Former in Crystal Engineering |
| title_full | Exploration of Fulvic Acid as a Co-Former in Crystal Engineering |
| title_fullStr | Exploration of Fulvic Acid as a Co-Former in Crystal Engineering |
| title_full_unstemmed | Exploration of Fulvic Acid as a Co-Former in Crystal Engineering |
| title_short | Exploration of Fulvic Acid as a Co-Former in Crystal Engineering |
| title_sort | exploration of fulvic acid as a co former in crystal engineering |
| topic | nutraceutical co-crystals curcumin quercetin semi crystalline SNMR |
| url | https://www.mdpi.com/2297-8739/9/5/126 |
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