HISTOGENESIS AND MOLECULAR DEVELOPMENT OF THE LUNG IN NEW ZEALAND WHITE RABBIT (Oryctolagus cuniculus)
In investigating fetal organ development, fetus of the rabbit was one of the furthermost frequently handled as a model in animal investigational research. During the second half of gestation in rabbit fetuses thorax volume (TV) was the predictive factor for assessment of normal development. Concern...
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| Format: | Article |
| Language: | English |
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University of Ljubljana Press (Založba Univerze v Ljubljani)
2021-12-01
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| Series: | Slovenian Veterinary Research |
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| Online Access: | https://www.slovetres.si/index.php/SVR/article/view/1453 |
| _version_ | 1797225044696367104 |
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| author | Esraa M. Abdelbadea Saeed M.S. Ammar Khaled Z. Soliman Mervat M.H. Konsowa |
| author_facet | Esraa M. Abdelbadea Saeed M.S. Ammar Khaled Z. Soliman Mervat M.H. Konsowa |
| author_sort | Esraa M. Abdelbadea |
| collection | DOAJ |
| description |
In investigating fetal organ development, fetus of the rabbit was one of the furthermost frequently handled as a model in animal investigational research. During the second half of gestation in rabbit fetuses thorax volume (TV) was the predictive factor for assessment of normal development. Concerning these fetuses, evaluation of lung development was more applicable in the 20th–29th gestational days for experiments. A large internal surface area in which the inspired air and capillary blood got in close contact to each other was specified by the lung tissue. Consequently, an efficient gas exchange was occurred. A cycle of separate but overlapping developmental processes happened to reach this target. The anlage of the left and right lungs appeared as an outpouching of the foregut endoderm during organogenesis. A repetitive process of outgrowth and branching pattern (branching morphogenesis) was occurred in each lung bud. Consequently, all of the future airways were formed mainly during the pseudoglandular stage. Repetitive airspace septation would lead to tremendous increase of the gas exchange surface area in both late fetal and postnatal lung development leading to the formation of alveoli. The first air-blood barriers were appeared and surfactant production began during the canalicular stage.
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| first_indexed | 2024-04-24T14:02:45Z |
| format | Article |
| id | doaj.art-ee34f79ddea74ef68df20a4fd669687a |
| institution | Directory Open Access Journal |
| issn | 1580-4003 2385-8761 |
| language | English |
| last_indexed | 2024-04-24T14:02:45Z |
| publishDate | 2021-12-01 |
| publisher | University of Ljubljana Press (Založba Univerze v Ljubljani) |
| record_format | Article |
| series | Slovenian Veterinary Research |
| spelling | doaj.art-ee34f79ddea74ef68df20a4fd669687a2024-04-03T12:38:21ZengUniversity of Ljubljana Press (Založba Univerze v Ljubljani)Slovenian Veterinary Research1580-40032385-87612021-12-015824-Suppl10.26873/SVR-1453-2021HISTOGENESIS AND MOLECULAR DEVELOPMENT OF THE LUNG IN NEW ZEALAND WHITE RABBIT (Oryctolagus cuniculus)Esraa M. Abdelbadea0Saeed M.S. Ammar1Khaled Z. Soliman2Mervat M.H. Konsowa3Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Zagazig University, Alzeraa Street, Post code 44511, Zagazig City, Sharkia Province, Egypt; , mmkonsoa@vet.zu.edu.egDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Zagazig University, Alzeraa Street, Post code 44511, Zagazig City, Sharkia Province, EgyptDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Zagazig University, Alzeraa Street, Post code 44511, Zagazig City, Sharkia Province, EgyptDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Zagazig University, Alzeraa Street, Post code 44511, Zagazig City, Sharkia Province, Egypt In investigating fetal organ development, fetus of the rabbit was one of the furthermost frequently handled as a model in animal investigational research. During the second half of gestation in rabbit fetuses thorax volume (TV) was the predictive factor for assessment of normal development. Concerning these fetuses, evaluation of lung development was more applicable in the 20th–29th gestational days for experiments. A large internal surface area in which the inspired air and capillary blood got in close contact to each other was specified by the lung tissue. Consequently, an efficient gas exchange was occurred. A cycle of separate but overlapping developmental processes happened to reach this target. The anlage of the left and right lungs appeared as an outpouching of the foregut endoderm during organogenesis. A repetitive process of outgrowth and branching pattern (branching morphogenesis) was occurred in each lung bud. Consequently, all of the future airways were formed mainly during the pseudoglandular stage. Repetitive airspace septation would lead to tremendous increase of the gas exchange surface area in both late fetal and postnatal lung development leading to the formation of alveoli. The first air-blood barriers were appeared and surfactant production began during the canalicular stage. https://www.slovetres.si/index.php/SVR/article/view/1453rabbit fetuslung developmentbranching morphogenesisalveoli |
| spellingShingle | Esraa M. Abdelbadea Saeed M.S. Ammar Khaled Z. Soliman Mervat M.H. Konsowa HISTOGENESIS AND MOLECULAR DEVELOPMENT OF THE LUNG IN NEW ZEALAND WHITE RABBIT (Oryctolagus cuniculus) Slovenian Veterinary Research rabbit fetus lung development branching morphogenesis alveoli |
| title | HISTOGENESIS AND MOLECULAR DEVELOPMENT OF THE LUNG IN NEW ZEALAND WHITE RABBIT (Oryctolagus cuniculus) |
| title_full | HISTOGENESIS AND MOLECULAR DEVELOPMENT OF THE LUNG IN NEW ZEALAND WHITE RABBIT (Oryctolagus cuniculus) |
| title_fullStr | HISTOGENESIS AND MOLECULAR DEVELOPMENT OF THE LUNG IN NEW ZEALAND WHITE RABBIT (Oryctolagus cuniculus) |
| title_full_unstemmed | HISTOGENESIS AND MOLECULAR DEVELOPMENT OF THE LUNG IN NEW ZEALAND WHITE RABBIT (Oryctolagus cuniculus) |
| title_short | HISTOGENESIS AND MOLECULAR DEVELOPMENT OF THE LUNG IN NEW ZEALAND WHITE RABBIT (Oryctolagus cuniculus) |
| title_sort | histogenesis and molecular development of the lung in new zealand white rabbit oryctolagus cuniculus |
| topic | rabbit fetus lung development branching morphogenesis alveoli |
| url | https://www.slovetres.si/index.php/SVR/article/view/1453 |
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