Periodontal disease and the risk of prostate cancer: a meta-analysis of cohort studies
ABSTRACT Background: Periodontal disease is reportedly associated with the risk of various systemic diseases, including pancreatic and lung cancers. However, its association with prostate cancer remains inconclusive. Herein, we explored the association of periodontal disease with the risk of prosta...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2021-10-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382021000601120&tlng=en |
| _version_ | 1798015611588050944 |
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| author | Zhenlang Guo Chiming Gu Siyi Li Shu Gan Yuan Li Songtao Xiang Leiliang Gong Shusheng Wang |
| author_facet | Zhenlang Guo Chiming Gu Siyi Li Shu Gan Yuan Li Songtao Xiang Leiliang Gong Shusheng Wang |
| author_sort | Zhenlang Guo |
| collection | DOAJ |
| description | ABSTRACT Background: Periodontal disease is reportedly associated with the risk of various systemic diseases, including pancreatic and lung cancers. However, its association with prostate cancer remains inconclusive. Herein, we explored the association of periodontal disease with the risk of prostate cancer through a meta-analysis. Materials and Methods: MEDLINE, Embase, Web of Sciences and Cochrane Library databases were searched for eligible publications up to April 2020. Multivariate adjusted risk estimates with corresponding 95% confidence intervals (CIs) were extracted and calculated using random- or fixed-effect models. Results: Nine cohort studies involving 3.353 prostate cancer cases with 440.911 participants were identified and included in the meta-analysis. We found that periodontal disease significantly increased the risk of prostate cancer by 1.40-fold (hazard ratio [HR]=1.40, 95% CI: 1.16-1.70; P=0.001; I2=76.1%) compared with normal condition. Interestingly, the risk of developing prostate cancer was not significant in patients treated with periodontal therapy (HR=1.22, 95% CI: 0.86-1.73; P=0.272; I2=65.2%). The results of subgroup analyses were also consistent and significant when stratified by study design and follow-up period, whereas conflicting results were observed in periodontal disease ascertainment stratification. These findings were robust as indicated by sensitivity analyses. Conclusions: Periodontal disease was associated with the increased risk of prostate cancer, whereas no significant association was observed in patients treated with periodontal therapy. Hence, the awareness and importance for maintaining oral health should be improved, and the underlying mechanisms linking periodontal disease and prostate cancer should be fully explored in future research. |
| first_indexed | 2024-04-11T15:37:34Z |
| format | Article |
| id | doaj.art-ee35d65ec6d547cca3326830a75d9510 |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-04-11T15:37:34Z |
| publishDate | 2021-10-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-ee35d65ec6d547cca3326830a75d95102022-12-22T04:15:55ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192021-10-014761120113010.1590/s1677-5538.ibju.2020.0333Periodontal disease and the risk of prostate cancer: a meta-analysis of cohort studiesZhenlang GuoChiming GuSiyi LiShu GanYuan LiSongtao XiangLeiliang GongShusheng Wanghttps://orcid.org/0000-0002-4567-3407ABSTRACT Background: Periodontal disease is reportedly associated with the risk of various systemic diseases, including pancreatic and lung cancers. However, its association with prostate cancer remains inconclusive. Herein, we explored the association of periodontal disease with the risk of prostate cancer through a meta-analysis. Materials and Methods: MEDLINE, Embase, Web of Sciences and Cochrane Library databases were searched for eligible publications up to April 2020. Multivariate adjusted risk estimates with corresponding 95% confidence intervals (CIs) were extracted and calculated using random- or fixed-effect models. Results: Nine cohort studies involving 3.353 prostate cancer cases with 440.911 participants were identified and included in the meta-analysis. We found that periodontal disease significantly increased the risk of prostate cancer by 1.40-fold (hazard ratio [HR]=1.40, 95% CI: 1.16-1.70; P=0.001; I2=76.1%) compared with normal condition. Interestingly, the risk of developing prostate cancer was not significant in patients treated with periodontal therapy (HR=1.22, 95% CI: 0.86-1.73; P=0.272; I2=65.2%). The results of subgroup analyses were also consistent and significant when stratified by study design and follow-up period, whereas conflicting results were observed in periodontal disease ascertainment stratification. These findings were robust as indicated by sensitivity analyses. Conclusions: Periodontal disease was associated with the increased risk of prostate cancer, whereas no significant association was observed in patients treated with periodontal therapy. Hence, the awareness and importance for maintaining oral health should be improved, and the underlying mechanisms linking periodontal disease and prostate cancer should be fully explored in future research.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382021000601120&tlng=enPeriodontal DiseasesProstatic NeoplasmsSystematic Review [Publication Type] |
| spellingShingle | Zhenlang Guo Chiming Gu Siyi Li Shu Gan Yuan Li Songtao Xiang Leiliang Gong Shusheng Wang Periodontal disease and the risk of prostate cancer: a meta-analysis of cohort studies International Brazilian Journal of Urology Periodontal Diseases Prostatic Neoplasms Systematic Review [Publication Type] |
| title | Periodontal disease and the risk of prostate cancer: a meta-analysis of cohort studies |
| title_full | Periodontal disease and the risk of prostate cancer: a meta-analysis of cohort studies |
| title_fullStr | Periodontal disease and the risk of prostate cancer: a meta-analysis of cohort studies |
| title_full_unstemmed | Periodontal disease and the risk of prostate cancer: a meta-analysis of cohort studies |
| title_short | Periodontal disease and the risk of prostate cancer: a meta-analysis of cohort studies |
| title_sort | periodontal disease and the risk of prostate cancer a meta analysis of cohort studies |
| topic | Periodontal Diseases Prostatic Neoplasms Systematic Review [Publication Type] |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382021000601120&tlng=en |
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