Prevalence and prognostic significance of malnutrition in early-stage multiple system atrophy
BackgroundMalnutrition is associated with poor survival in some diseases. However, the nutritional status in multiple system atrophy (MSA) is unknown, and the significance of malnutrition for the prediction of mortality in MSA has not been well established.ObjectiveWe aimed to determine the prevalen...
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| Format: | Article |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1248349/full |
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| author | Shirong Li Shirong Li Lingyu Zhang Yanbing Hou Tianmi Yang Chunyu Li Qianqian Wei Ruwei Ou Xueping Chen Huifang Shang |
| author_facet | Shirong Li Shirong Li Lingyu Zhang Yanbing Hou Tianmi Yang Chunyu Li Qianqian Wei Ruwei Ou Xueping Chen Huifang Shang |
| author_sort | Shirong Li |
| collection | DOAJ |
| description | BackgroundMalnutrition is associated with poor survival in some diseases. However, the nutritional status in multiple system atrophy (MSA) is unknown, and the significance of malnutrition for the prediction of mortality in MSA has not been well established.ObjectiveWe aimed to determine the prevalence of malnutrition and the prognostic value of malnutrition in patients with early-stage MSA.MethodsPatients diagnosed with early phase MSA (disease duration<3 years) were recruited, and they were followed every year until May 2023. The nutritional status of patients with MSA was assessed using the Controlling Nutritional Status (CONUT) score and Geriatric Nutritional Risk Index (GNRI). Kaplan–Meier survival analysis and Cox regression model were used to assess the prognostic value of malnutrition in MSA.ResultsA total of 224 patients with probable MSA (106 MSA died and 118 were still alive) and 213 matched healthy controls (HCs) were enrolled. According to COUNT score and GNRI, patients with MSA had higher prevalence of malnutrition than HCs (44.6% vs. 14.1 and 17.9% vs. 0.9%, respectively). The median survival from symptom onset in patients with MSA in the malnutrition group was shorter than those in the normal-nutrition group (5.98 vs. 7.06 years, p = 0.012) by COUNT score. Additionally, malnutrition increased the risk of mortality in patients with MSA (HR = 1.556, p = 0.030) and MSA-P (HR = 1.973, p = 0.042) by COUNT score.InterpretationMalnutrition was common in patients with early-stage MSA. Malnutrition increased the risk of mortality in patients with MSA, and early nutritional supplementation should be taken into consideration. |
| first_indexed | 2024-03-10T00:33:01Z |
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| language | English |
| last_indexed | 2024-03-10T00:33:01Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-ee3665de5ca04d88bf9a9071db9a4ebc2023-11-23T15:22:49ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-11-011010.3389/fnut.2023.12483491248349Prevalence and prognostic significance of malnutrition in early-stage multiple system atrophyShirong Li0Shirong Li1Lingyu Zhang2Yanbing Hou3Tianmi Yang4Chunyu Li5Qianqian Wei6Ruwei Ou7Xueping Chen8Huifang Shang9Laboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaBackgroundMalnutrition is associated with poor survival in some diseases. However, the nutritional status in multiple system atrophy (MSA) is unknown, and the significance of malnutrition for the prediction of mortality in MSA has not been well established.ObjectiveWe aimed to determine the prevalence of malnutrition and the prognostic value of malnutrition in patients with early-stage MSA.MethodsPatients diagnosed with early phase MSA (disease duration<3 years) were recruited, and they were followed every year until May 2023. The nutritional status of patients with MSA was assessed using the Controlling Nutritional Status (CONUT) score and Geriatric Nutritional Risk Index (GNRI). Kaplan–Meier survival analysis and Cox regression model were used to assess the prognostic value of malnutrition in MSA.ResultsA total of 224 patients with probable MSA (106 MSA died and 118 were still alive) and 213 matched healthy controls (HCs) were enrolled. According to COUNT score and GNRI, patients with MSA had higher prevalence of malnutrition than HCs (44.6% vs. 14.1 and 17.9% vs. 0.9%, respectively). The median survival from symptom onset in patients with MSA in the malnutrition group was shorter than those in the normal-nutrition group (5.98 vs. 7.06 years, p = 0.012) by COUNT score. Additionally, malnutrition increased the risk of mortality in patients with MSA (HR = 1.556, p = 0.030) and MSA-P (HR = 1.973, p = 0.042) by COUNT score.InterpretationMalnutrition was common in patients with early-stage MSA. Malnutrition increased the risk of mortality in patients with MSA, and early nutritional supplementation should be taken into consideration.https://www.frontiersin.org/articles/10.3389/fnut.2023.1248349/fullmultiple system atrophycontrolling nutritional status scoremalnutritionsurvivalcohort study |
| spellingShingle | Shirong Li Shirong Li Lingyu Zhang Yanbing Hou Tianmi Yang Chunyu Li Qianqian Wei Ruwei Ou Xueping Chen Huifang Shang Prevalence and prognostic significance of malnutrition in early-stage multiple system atrophy Frontiers in Nutrition multiple system atrophy controlling nutritional status score malnutrition survival cohort study |
| title | Prevalence and prognostic significance of malnutrition in early-stage multiple system atrophy |
| title_full | Prevalence and prognostic significance of malnutrition in early-stage multiple system atrophy |
| title_fullStr | Prevalence and prognostic significance of malnutrition in early-stage multiple system atrophy |
| title_full_unstemmed | Prevalence and prognostic significance of malnutrition in early-stage multiple system atrophy |
| title_short | Prevalence and prognostic significance of malnutrition in early-stage multiple system atrophy |
| title_sort | prevalence and prognostic significance of malnutrition in early stage multiple system atrophy |
| topic | multiple system atrophy controlling nutritional status score malnutrition survival cohort study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1248349/full |
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