Do we know enough to find an adjunctive therapy for cerebral malaria in African children? [version 1; referees: 2 approved]
Cerebral malaria is the deadliest complication of malaria, a febrile infectious disease caused by Plasmodium parasite. Any of the five human Plasmodium species can cause disease, but, for unknown reasons, in approximately 2 million cases each year P. falciparum progresses to severe disease, ultimate...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2017-11-01
|
| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/6-2039/v1 |
| _version_ | 1818205200704339968 |
|---|---|
| author | Brittany A. Riggle Louis H. Miller Susan K. Pierce |
| author_facet | Brittany A. Riggle Louis H. Miller Susan K. Pierce |
| author_sort | Brittany A. Riggle |
| collection | DOAJ |
| description | Cerebral malaria is the deadliest complication of malaria, a febrile infectious disease caused by Plasmodium parasite. Any of the five human Plasmodium species can cause disease, but, for unknown reasons, in approximately 2 million cases each year P. falciparum progresses to severe disease, ultimately resulting in half a million deaths. The majority of these deaths are in children under the age of five. Currently, there is no way to predict which child will progress to severe disease and there are no adjunctive therapies to halt the symptoms after onset. Herein, we discuss what is known about the disease mechanism of one form of severe malaria, cerebral malaria, and how we might exploit this understanding to rescue children in the throes of cerebral disease. |
| first_indexed | 2024-12-12T03:53:21Z |
| format | Article |
| id | doaj.art-ee367001138c4251aeb037501aafc1c8 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-12T03:53:21Z |
| publishDate | 2017-11-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-ee367001138c4251aeb037501aafc1c82022-12-22T00:39:20ZengF1000 Research LtdF1000Research2046-14022017-11-01610.12688/f1000research.12401.113430Do we know enough to find an adjunctive therapy for cerebral malaria in African children? [version 1; referees: 2 approved]Brittany A. Riggle0Louis H. Miller1Susan K. Pierce2Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, USALaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, USALaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, USACerebral malaria is the deadliest complication of malaria, a febrile infectious disease caused by Plasmodium parasite. Any of the five human Plasmodium species can cause disease, but, for unknown reasons, in approximately 2 million cases each year P. falciparum progresses to severe disease, ultimately resulting in half a million deaths. The majority of these deaths are in children under the age of five. Currently, there is no way to predict which child will progress to severe disease and there are no adjunctive therapies to halt the symptoms after onset. Herein, we discuss what is known about the disease mechanism of one form of severe malaria, cerebral malaria, and how we might exploit this understanding to rescue children in the throes of cerebral disease.https://f1000research.com/articles/6-2039/v1Immunity to InfectionsInnate ImmunityMedical MicrobiologyParasitologyPediatric Infectious DiseasesTropical & Travel-Associated Diseases |
| spellingShingle | Brittany A. Riggle Louis H. Miller Susan K. Pierce Do we know enough to find an adjunctive therapy for cerebral malaria in African children? [version 1; referees: 2 approved] F1000Research Immunity to Infections Innate Immunity Medical Microbiology Parasitology Pediatric Infectious Diseases Tropical & Travel-Associated Diseases |
| title | Do we know enough to find an adjunctive therapy for cerebral malaria in African children? [version 1; referees: 2 approved] |
| title_full | Do we know enough to find an adjunctive therapy for cerebral malaria in African children? [version 1; referees: 2 approved] |
| title_fullStr | Do we know enough to find an adjunctive therapy for cerebral malaria in African children? [version 1; referees: 2 approved] |
| title_full_unstemmed | Do we know enough to find an adjunctive therapy for cerebral malaria in African children? [version 1; referees: 2 approved] |
| title_short | Do we know enough to find an adjunctive therapy for cerebral malaria in African children? [version 1; referees: 2 approved] |
| title_sort | do we know enough to find an adjunctive therapy for cerebral malaria in african children version 1 referees 2 approved |
| topic | Immunity to Infections Innate Immunity Medical Microbiology Parasitology Pediatric Infectious Diseases Tropical & Travel-Associated Diseases |
| url | https://f1000research.com/articles/6-2039/v1 |
| work_keys_str_mv | AT brittanyariggle doweknowenoughtofindanadjunctivetherapyforcerebralmalariainafricanchildrenversion1referees2approved AT louishmiller doweknowenoughtofindanadjunctivetherapyforcerebralmalariainafricanchildrenversion1referees2approved AT susankpierce doweknowenoughtofindanadjunctivetherapyforcerebralmalariainafricanchildrenversion1referees2approved |