Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies
Magnesium, an essential cation for numerous cellular processes, is a major component of bone. However, its relationship with the risk of fractures is still uncertain. The present systematic review and meta-analysis aim to investigate the impact of serum Mg on the risk of incident fractures. A system...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/6/1304 |
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| author | Ligia J. Dominguez Nicola Veronese Stefano Ciriminna José Luis Pérez-Albela Vania Flora Vásquez-López Santiago Rodas-Regalado Giovanna Di Bella Angela Parisi Federica Tagliaferri Mario Barbagallo |
| author_facet | Ligia J. Dominguez Nicola Veronese Stefano Ciriminna José Luis Pérez-Albela Vania Flora Vásquez-López Santiago Rodas-Regalado Giovanna Di Bella Angela Parisi Federica Tagliaferri Mario Barbagallo |
| author_sort | Ligia J. Dominguez |
| collection | DOAJ |
| description | Magnesium, an essential cation for numerous cellular processes, is a major component of bone. However, its relationship with the risk of fractures is still uncertain. The present systematic review and meta-analysis aim to investigate the impact of serum Mg on the risk of incident fractures. A systematic search was conducted using several databases including PubMed/Medline and Scopus from inception to 24 May 2022, including observational studies investigating serum Mg and the incidence of fractures considered as outcomes. Abstract and full-text screenings, data extractions, and risk of bias assessments were conducted by two investigators independently. Any inconsistencies were resolved by consensus with a third author. The Newcastle–Ottawa Scale was used to assess the study quality/risk of bias. Among 1332 records initially screened, 16 were retrieved as full-texts; of them, four papers were included in the systematic review with a total of 119,755 participants. We found that lower serum Mg concentrations were associated with a significantly higher risk of incident fractures (RR = 1.579; 95%CI: 1.216–2.051; <i>p</i> = 0.001; I<sup>2</sup> = 46.9%). Our systematic review with meta-analysis suggests a strong association of serum Mg concentrations with incident fractures. Further research is needed to confirm our results among other populations and to assess whether serum Mg is potentially relevant in the prevention of fractures, which continue to increase and represent a significant health burden due to the associated disability. |
| first_indexed | 2024-03-11T06:05:40Z |
| format | Article |
| id | doaj.art-ee36e09ff63e4da9a26941e10c264ade |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T06:05:40Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ee36e09ff63e4da9a26941e10c264ade2023-11-17T13:03:55ZengMDPI AGNutrients2072-66432023-03-01156130410.3390/nu15061304Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational StudiesLigia J. Dominguez0Nicola Veronese1Stefano Ciriminna2José Luis Pérez-Albela3Vania Flora Vásquez-López4Santiago Rodas-Regalado5Giovanna Di Bella6Angela Parisi7Federica Tagliaferri8Mario Barbagallo9Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90133 Palermo, ItalyGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90133 Palermo, ItalyGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90133 Palermo, ItalyInstituto Bien de Salud, Lima 15036, PeruInstituto Bien de Salud, Lima 15036, PeruInstituto Bien de Salud, Lima 15036, PeruGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90133 Palermo, ItalyGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90133 Palermo, ItalyGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90133 Palermo, ItalyGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90133 Palermo, ItalyMagnesium, an essential cation for numerous cellular processes, is a major component of bone. However, its relationship with the risk of fractures is still uncertain. The present systematic review and meta-analysis aim to investigate the impact of serum Mg on the risk of incident fractures. A systematic search was conducted using several databases including PubMed/Medline and Scopus from inception to 24 May 2022, including observational studies investigating serum Mg and the incidence of fractures considered as outcomes. Abstract and full-text screenings, data extractions, and risk of bias assessments were conducted by two investigators independently. Any inconsistencies were resolved by consensus with a third author. The Newcastle–Ottawa Scale was used to assess the study quality/risk of bias. Among 1332 records initially screened, 16 were retrieved as full-texts; of them, four papers were included in the systematic review with a total of 119,755 participants. We found that lower serum Mg concentrations were associated with a significantly higher risk of incident fractures (RR = 1.579; 95%CI: 1.216–2.051; <i>p</i> = 0.001; I<sup>2</sup> = 46.9%). Our systematic review with meta-analysis suggests a strong association of serum Mg concentrations with incident fractures. Further research is needed to confirm our results among other populations and to assess whether serum Mg is potentially relevant in the prevention of fractures, which continue to increase and represent a significant health burden due to the associated disability.https://www.mdpi.com/2072-6643/15/6/1304magnesiumfractureosteoporosismeta-analysisrisk factoraging |
| spellingShingle | Ligia J. Dominguez Nicola Veronese Stefano Ciriminna José Luis Pérez-Albela Vania Flora Vásquez-López Santiago Rodas-Regalado Giovanna Di Bella Angela Parisi Federica Tagliaferri Mario Barbagallo Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies Nutrients magnesium fracture osteoporosis meta-analysis risk factor aging |
| title | Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies |
| title_full | Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies |
| title_fullStr | Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies |
| title_full_unstemmed | Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies |
| title_short | Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies |
| title_sort | association between serum magnesium and fractures a systematic review and meta analysis of observational studies |
| topic | magnesium fracture osteoporosis meta-analysis risk factor aging |
| url | https://www.mdpi.com/2072-6643/15/6/1304 |
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