The Importance of miRNA in the Diagnosis and Prognosis of Papillary Thyroid Cancer
In recent years, the global incidence of thyroid cancer has been increasing. Despite the significant progress in the diagnostic tools applied for papillary thyroid cancer (PTC) diagnosis, commonly used methods require undergoing invasive diagnostic procedures, such as liquid biopsy, which still, in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/20/4738 |
| _version_ | 1797514278605946880 |
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| author | Mariusz Rogucki Angelika Buczyńska Adam Jacek Krętowski Anna Popławska-Kita |
| author_facet | Mariusz Rogucki Angelika Buczyńska Adam Jacek Krętowski Anna Popławska-Kita |
| author_sort | Mariusz Rogucki |
| collection | DOAJ |
| description | In recent years, the global incidence of thyroid cancer has been increasing. Despite the significant progress in the diagnostic tools applied for papillary thyroid cancer (PTC) diagnosis, commonly used methods require undergoing invasive diagnostic procedures, such as liquid biopsy, which still, in some cases, remains imprecise. In this case, novel screening and diagnostic biomarkers are still being evaluated using highly specialized techniques, which could increase PTC detection. Currently, a number of genes and proteins associated with PTC development are currently under investigation to assess their clinical utility. Accordingly, a literature search was undertaken to collect novel information about the diagnosis of and prognosis for PTC with a particular emphasis on the role of microRNA (miRNA) evaluation. The early identification of novel biomarkers is essential for facilitating appropriate therapeutic decisions. Moreover, the evaluation of plasma- and serum-derived miRNA measurements could be considered as equivalent thyroid cancer screening tools in the future. On the other hand, the PTC pathogenesis could be evaluated further with the use of miRNA evaluation, which may bring novel insights for potential medical target determination. |
| first_indexed | 2024-03-10T06:29:21Z |
| format | Article |
| id | doaj.art-ee3c5c7f6b5c45ce93fa1b6925d35157 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T06:29:21Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ee3c5c7f6b5c45ce93fa1b6925d351572023-11-22T18:42:28ZengMDPI AGJournal of Clinical Medicine2077-03832021-10-011020473810.3390/jcm10204738The Importance of miRNA in the Diagnosis and Prognosis of Papillary Thyroid CancerMariusz Rogucki0Angelika Buczyńska1Adam Jacek Krętowski2Anna Popławska-Kita3Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, PolandClinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, PolandIn recent years, the global incidence of thyroid cancer has been increasing. Despite the significant progress in the diagnostic tools applied for papillary thyroid cancer (PTC) diagnosis, commonly used methods require undergoing invasive diagnostic procedures, such as liquid biopsy, which still, in some cases, remains imprecise. In this case, novel screening and diagnostic biomarkers are still being evaluated using highly specialized techniques, which could increase PTC detection. Currently, a number of genes and proteins associated with PTC development are currently under investigation to assess their clinical utility. Accordingly, a literature search was undertaken to collect novel information about the diagnosis of and prognosis for PTC with a particular emphasis on the role of microRNA (miRNA) evaluation. The early identification of novel biomarkers is essential for facilitating appropriate therapeutic decisions. Moreover, the evaluation of plasma- and serum-derived miRNA measurements could be considered as equivalent thyroid cancer screening tools in the future. On the other hand, the PTC pathogenesis could be evaluated further with the use of miRNA evaluation, which may bring novel insights for potential medical target determination.https://www.mdpi.com/2077-0383/10/20/4738miRNApapillary thyroid cancerdiagnosisscreening |
| spellingShingle | Mariusz Rogucki Angelika Buczyńska Adam Jacek Krętowski Anna Popławska-Kita The Importance of miRNA in the Diagnosis and Prognosis of Papillary Thyroid Cancer Journal of Clinical Medicine miRNA papillary thyroid cancer diagnosis screening |
| title | The Importance of miRNA in the Diagnosis and Prognosis of Papillary Thyroid Cancer |
| title_full | The Importance of miRNA in the Diagnosis and Prognosis of Papillary Thyroid Cancer |
| title_fullStr | The Importance of miRNA in the Diagnosis and Prognosis of Papillary Thyroid Cancer |
| title_full_unstemmed | The Importance of miRNA in the Diagnosis and Prognosis of Papillary Thyroid Cancer |
| title_short | The Importance of miRNA in the Diagnosis and Prognosis of Papillary Thyroid Cancer |
| title_sort | importance of mirna in the diagnosis and prognosis of papillary thyroid cancer |
| topic | miRNA papillary thyroid cancer diagnosis screening |
| url | https://www.mdpi.com/2077-0383/10/20/4738 |
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