Structural View of Cryo-Electron Microscopy-Determined ATP-Binding Cassette Transporters in Human Multidrug Resistance

Structural View of Cryo-Electron Microscopy-Determined ATP-Binding Cassette Transporters in Human Multidrug Resistance

ATP-binding cassette (ABC) transporters, acting as cellular “pumps,” facilitate solute translocation through membranes via ATP hydrolysis. Their overexpression is closely tied to multidrug resistance (MDR), a major obstacle in chemotherapy and neurological disorder treatment, hampering drug accumula...

Full description

Bibliographic Details
Main Authors:	Wenjie Fan, Kai Shao, Min Luo
Format:	Article
Language:	English
Published:	MDPI AG 2024-02-01
Series:	Biomolecules
Subjects:	multidrug resistance ABC transporter cancer cryo-electron microscopy
Online Access:	https://www.mdpi.com/2218-273X/14/2/231

Similar Items

Expression of some ATP-binding cassette transporters in acute myeloid leukemia
by: Antonella Maria Salvia, et al.
Published: (2017-12-01)

Repositioning of Tyrosine Kinase Inhibitors as Antagonists of ATP-Binding Cassette Transporters in Anticancer Drug Resistance
by: Yi-Jun Wang, et al.
Published: (2014-09-01)

Mass Spectrometry Investigation of Some ATP-Binding Cassette (ABC) Proteins
by: Marco Agostini, et al.
Published: (2024-01-01)

Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses
by: Ling Wang, et al.
Published: (2020-05-01)

Identification and Characterization of ATP-Binding Cassette Transporters in <i>Chlamydomonas reinhardtii</i>
by: Xiangyu Li, et al.
Published: (2022-09-01)

Cryo-electron Microscopy Structure and Transport Mechanism of a Wall Teichoic Acid ABC Transporter
by: Li Chen, et al.
Published: (2020-04-01)

Tomato ATP-Binding Cassette Transporter SlABCB4 Is Involved in Auxin Transport in the Developing Fruit
by: Peter Amoako Ofori, et al.
Published: (2018-08-01)

Predicting ATP-Binding Cassette Transporters Using the Random Forest Method
by: Ruiyan Hou, et al.
Published: (2020-03-01)

The pharmacological impact of ATP-binding cassette drug transporters on vemurafenib-based therapy
by: Chung-Pu Wu, et al.
Published: (2014-04-01)

Editorial: Technical Advances in Cryo-Electron Microscopy
by: Angel Rivera-Calzada, et al.
Published: (2019-08-01)

NVP-CGM097, an HDM2 Inhibitor, Antagonizes ATP-Binding Cassette Subfamily B Member 1-Mediated Drug Resistance
by: Meng Zhang, et al.
Published: (2020-07-01)

Up-regulation of ATP-binding cassette transporters in the THP-1 human macrophage cell line by the antichagasic benznidazole
by: Virginia G Perdomo, et al.

Human ATP-binding cassette (ABC) transporter family
by: Vasiliou Vasilis, et al.
Published: (2009-04-01)

ATP-binding cassette transporters mediate differential biosynthesis of glycosphingolipid species
by: Monique Budani, et al.
Published: (2021-01-01)

Cardiac PET Imaging of ATP Binding Cassette (ABC) Transporters: Opportunities and Challenges
by: Wanling Liu, et al.
Published: (2023-12-01)

Evaluation of the role of ATP-binding cassette transporters as a defence mechanism against temephos in populations of Aedes aegypti
by: Estelita Pereira Lima, et al.
Published: (2014-11-01)

The capacity of Listeria monocytogenes mutants with in-frame deletions in putative ATP-binding cassette transporters to form biofilms and comparison with the wild type
by: Marina Ceruso, et al.
Published: (2014-02-01)

The Role of ATP-Binding Cassette Proteins in Stem Cell Pluripotency
by: Prince Saini, et al.
Published: (2023-06-01)

An ATP-Binding Cassette Transporter, LaABCB11, Contributes to Alkaloid Transport in <i>Lycoris aurea</i>
by: Rong Wang, et al.
Published: (2021-10-01)

PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy
by: Sergey Gorelick, et al.
Published: (2019-07-01)

A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance
by: Jiahui Huang, et al.
Published: (2023-01-01)

Identification and Expression Characterization of ATP-Binding Cassette (ABC) Transporter Genes in Melon Fly
by: Hui-Qian Xu, et al.
Published: (2021-03-01)

Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance
by: Zhemin Zhang, et al.
Published: (2023-08-01)

Increased expression of ATP‐binding cassette transporters in enfortumab vedotin‐resistant urothelial cancer
by: Mariko Kotono, et al.
Published: (2024-03-01)

The potential roles of retinoids in combating drug resistance in cancer: implications of ATP-binding cassette (ABC) transporters
by: Mohamed R. Abdelaal, et al.
Published: (2022-06-01)

Involvement of LeMDR, an ATP-binding cassette protein gene, in shikonin transport and biosynthesis in Lithospermum erythrorhizon
by: Yu Zhu, et al.
Published: (2017-11-01)

Genome-wide analysis of ATP-binding cassette transporter provides insight to genes related to bioactive metabolite transportation in Salvia miltiorrhiza
by: Li Yan, et al.
Published: (2021-05-01)

Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing
by: Prochazkova Jirina, et al.
Published: (2012-08-01)

Genetic variation in the ATP binding cassette transporter ABCC10 is associated with neutropenia for docetaxel in Japanese lung cancer patients cohort
by: Kazuki Sone, et al.
Published: (2019-03-01)

Editorial: Methods in structural biology: Cryo-electron microscopy
by: Zongli Li, et al.
Published: (2022-11-01)

ABC Transporter Genes Show Upregulated Expression in Drug-Resistant Clinical Isolates of Candida auris: A Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes
by: Mohd Wasi, et al.
Published: (2019-07-01)

Transcriptional Response of ATP-Binding Cassette (ABC) Transporters to Insecticide in the Brown Planthopper, <i>Nilaparvata lugens</i> (Stål)
by: Zhao Li, et al.
Published: (2020-05-01)

The β Isoform of Human ATP-Binding Cassette B5 Transporter, ABCB5β, Localizes to the Endoplasmic Reticulum
by: Adriana María Díaz-Anaya, et al.
Published: (2023-10-01)

Cryo-Electron Microscopy Structure of an <named-content content-type="genus-species">Acinetobacter baumannii</named-content> Multidrug Efflux Pump
by: Chih-Chia Su, et al.
Published: (2019-08-01)

DeepRTCP: Predicting ATP-Binding Cassette Transporters Based on 1-Dimensional Convolutional Network
by: Zhaoxi Zhang, et al.
Published: (2021-02-01)

The ABCC6 transporter: what lessons can be learnt from other ATP-binding cassette transporters?
by: Olivier M. Vanakker, et al.
Published: (2013-10-01)

`Cryo-EM': electron cryomicroscopy, cryo electron microscopy or something else?
by: Richard Henderson, et al.
Published: (2023-09-01)

Functional analysis of the ATP-binding cassette (ABC) transporter gene family of <it>Tribolium castaneum</it>
by: Broehan Gunnar, et al.
Published: (2013-01-01)

Recent advances in retroviruses via cryo-electron microscopy
by: Johnson Mak, et al.
Published: (2018-02-01)

Structural and functional insights into the Diabrotica virgifera virgifera ATP-binding cassette transporter gene family
by: Folukemi Adedipe, et al.
Published: (2019-11-01)