Effect of Melatonin on Bone Mineral Density of Irradiated Rats
Objective: Melatonin is a powerful endogenous antioxidant and it may play a role in preventionof radiation-induced damage. The aim of this study was to investigate the effect ofmelatonin on bone mineral density in rats receiving radiation.Materials and Methods: Sprague Dawley rats were divided into...
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| Format: | Article |
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Royan Institute (ACECR), Tehran
2011-01-01
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| Series: | Cell Journal |
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| Online Access: | http://celljournal.org/library/upload/article/af_3722226Orbak.pdf |
| _version_ | 1818346809561448448 |
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| author | Zerrin Orbak Vecdi Ertekin Mustafa Yildirim Vildan Ertekin Bedri Seven Ihsan Karslioglu |
| author_facet | Zerrin Orbak Vecdi Ertekin Mustafa Yildirim Vildan Ertekin Bedri Seven Ihsan Karslioglu |
| author_sort | Zerrin Orbak |
| collection | DOAJ |
| description | Objective: Melatonin is a powerful endogenous antioxidant and it may play a role in preventionof radiation-induced damage. The aim of this study was to investigate the effect ofmelatonin on bone mineral density in rats receiving radiation.Materials and Methods: Sprague Dawley rats were divided into four groups. Group 1(control group) received neither melatonin nor radiation (control group). Group 2 (Melgroup) was administered intraperitoneal injections of 5mg/kg melatonin daily for ten days.Group 3 (RT group) and Group 4 were exposed to total cranium radiation of 5 Gy in a singledose by using a cobalt-60 teletherapy unit. In addition to irradiation, group 4 (RT + Melgroup) was administered 5mg/kg of melatonin intraperitoneally. At the end of the 10th day,the rats' cranium and vertebrae bone mineral densities (BMDs) were measured.Results: When cranial BMDs were evaluated, statistically more significant BMD increaseswere seen in the Mel group and the RT + Mel groups than in the control group. No significantdifference was seen in the Mel group versus the RT + Mel group; however, there wasa significant difference between RT and RT + Mel groups. When vertebral BMDs wereevaluated, the only significant difference was found between the control and Mel groups.Conclusion: We think that melatonin is a radioprotective agent. However, we would liketo emphasize that further studies are needed before clinical trials with melatonin are initiated. |
| first_indexed | 2024-12-13T17:24:10Z |
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| institution | Directory Open Access Journal |
| issn | 2228-5806 2228-5814 |
| language | English |
| last_indexed | 2024-12-13T17:24:10Z |
| publishDate | 2011-01-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | Cell Journal |
| spelling | doaj.art-ee3dcff9ba1244fd93e378441f0653362022-12-21T23:37:14ZengRoyan Institute (ACECR), TehranCell Journal2228-58062228-58142011-01-01124459462Effect of Melatonin on Bone Mineral Density of Irradiated RatsZerrin OrbakVecdi ErtekinMustafa YildirimVildan ErtekinBedri SevenIhsan KarsliogluObjective: Melatonin is a powerful endogenous antioxidant and it may play a role in preventionof radiation-induced damage. The aim of this study was to investigate the effect ofmelatonin on bone mineral density in rats receiving radiation.Materials and Methods: Sprague Dawley rats were divided into four groups. Group 1(control group) received neither melatonin nor radiation (control group). Group 2 (Melgroup) was administered intraperitoneal injections of 5mg/kg melatonin daily for ten days.Group 3 (RT group) and Group 4 were exposed to total cranium radiation of 5 Gy in a singledose by using a cobalt-60 teletherapy unit. In addition to irradiation, group 4 (RT + Melgroup) was administered 5mg/kg of melatonin intraperitoneally. At the end of the 10th day,the rats' cranium and vertebrae bone mineral densities (BMDs) were measured.Results: When cranial BMDs were evaluated, statistically more significant BMD increaseswere seen in the Mel group and the RT + Mel groups than in the control group. No significantdifference was seen in the Mel group versus the RT + Mel group; however, there wasa significant difference between RT and RT + Mel groups. When vertebral BMDs wereevaluated, the only significant difference was found between the control and Mel groups.Conclusion: We think that melatonin is a radioprotective agent. However, we would liketo emphasize that further studies are needed before clinical trials with melatonin are initiated.http://celljournal.org/library/upload/article/af_3722226Orbak.pdfMelatoninBone Mineral DensityRatIrradiation |
| spellingShingle | Zerrin Orbak Vecdi Ertekin Mustafa Yildirim Vildan Ertekin Bedri Seven Ihsan Karslioglu Effect of Melatonin on Bone Mineral Density of Irradiated Rats Cell Journal Melatonin Bone Mineral Density Rat Irradiation |
| title | Effect of Melatonin on Bone Mineral Density of Irradiated Rats |
| title_full | Effect of Melatonin on Bone Mineral Density of Irradiated Rats |
| title_fullStr | Effect of Melatonin on Bone Mineral Density of Irradiated Rats |
| title_full_unstemmed | Effect of Melatonin on Bone Mineral Density of Irradiated Rats |
| title_short | Effect of Melatonin on Bone Mineral Density of Irradiated Rats |
| title_sort | effect of melatonin on bone mineral density of irradiated rats |
| topic | Melatonin Bone Mineral Density Rat Irradiation |
| url | http://celljournal.org/library/upload/article/af_3722226Orbak.pdf |
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