Unraveling Aβ-Mediated Multi-Pathway Calcium Dynamics in Astrocytes: Implications for Alzheimer’s Disease Treatment From Simulations

Unraveling Aβ-Mediated Multi-Pathway Calcium Dynamics in Astrocytes: Implications for Alzheimer’s Disease Treatment From Simulations

The accumulation of amyloid β peptide (Aβ) in the brain is hypothesized to be the major factor driving Alzheimer’s disease (AD) pathogenesis. Mounting evidence suggests that astrocytes are the primary target of Aβ neurotoxicity. Aβ is known to interfere with multiple calcium fluxes, thus disrupting...

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Bibliographic Details
Main Authors: Langzhou Liu, Huayi Gao, Alexey Zaikin, Shangbin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Physiology
Subjects:
Aβ
Alzheimer’s disease
astrocyte
calcium oscillations
dyshomeostasis
therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.767892/full

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