Consequences of Real-World Surveillance of Fellow Eyes in Neovascular Age-Related Macular Degeneration
This study investigated whether the interval of monitoring at-risk, fellow eyes of patients with unilateral neovascular age-related macular degeneration (nAMD) has any bearing on the severity of the disease at the time of diagnosis. The study comprised a retrospective, cross-sectional comparative ca...
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MDPI AG
2023-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/2/385 |
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| author | Oluchukwu Onwuka Jackson L. Saddemi Fatma Sema Akkan Aydoğmuş Claudia C. Lasalle David J. Ramsey |
| author_facet | Oluchukwu Onwuka Jackson L. Saddemi Fatma Sema Akkan Aydoğmuş Claudia C. Lasalle David J. Ramsey |
| author_sort | Oluchukwu Onwuka |
| collection | DOAJ |
| description | This study investigated whether the interval of monitoring at-risk, fellow eyes of patients with unilateral neovascular age-related macular degeneration (nAMD) has any bearing on the severity of the disease at the time of diagnosis. The study comprised a retrospective, cross-sectional comparative case series of treatment-naïve eyes in patients who were diagnosed sequentially with nAMD. We compared the visual acuity (VA) and central macular thickness (CMT) of patients who were actively receiving intravitreal injections (IVIs) of anti-vascular endothelial growth factor (anti-VEGF) agents at the time of second eye diagnosis with the VA and CMT of patients who had ceased treatment in their first eye because of reaching end-stages of disease. Intervals of visits and frequency of monitoring the macula of fellow eyes by means of optical coherence tomography (OCT) were abstracted from the medical record. We found that the at-risk fellow eyes of patients who had stopped treatment for nAMD in their first eye prior to fellow eye conversion were monitored significantly less frequently than the fellow eyes of patients who continued to receive treatment at the time of second eye diagnosis. Despite less frequent monitoring, VA and CMT were similar at the time of fellow eye diagnosis for both groups. |
| first_indexed | 2024-03-11T08:32:58Z |
| format | Article |
| id | doaj.art-ee412c8e7a654d448805976c04c4d4dc |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:32:58Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-ee412c8e7a654d448805976c04c4d4dc2023-11-16T21:40:33ZengMDPI AGLife2075-17292023-01-0113238510.3390/life13020385Consequences of Real-World Surveillance of Fellow Eyes in Neovascular Age-Related Macular DegenerationOluchukwu Onwuka0Jackson L. Saddemi1Fatma Sema Akkan Aydoğmuş2Claudia C. Lasalle3David J. Ramsey4Department of Surgery, Division of Ophthalmology, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, MA 01805, USADepartment of Surgery, Division of Ophthalmology, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, MA 01805, USADepartment of Surgery, Division of Ophthalmology, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, MA 01805, USADepartment of Surgery, Division of Ophthalmology, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, MA 01805, USADepartment of Surgery, Division of Ophthalmology, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, MA 01805, USAThis study investigated whether the interval of monitoring at-risk, fellow eyes of patients with unilateral neovascular age-related macular degeneration (nAMD) has any bearing on the severity of the disease at the time of diagnosis. The study comprised a retrospective, cross-sectional comparative case series of treatment-naïve eyes in patients who were diagnosed sequentially with nAMD. We compared the visual acuity (VA) and central macular thickness (CMT) of patients who were actively receiving intravitreal injections (IVIs) of anti-vascular endothelial growth factor (anti-VEGF) agents at the time of second eye diagnosis with the VA and CMT of patients who had ceased treatment in their first eye because of reaching end-stages of disease. Intervals of visits and frequency of monitoring the macula of fellow eyes by means of optical coherence tomography (OCT) were abstracted from the medical record. We found that the at-risk fellow eyes of patients who had stopped treatment for nAMD in their first eye prior to fellow eye conversion were monitored significantly less frequently than the fellow eyes of patients who continued to receive treatment at the time of second eye diagnosis. Despite less frequent monitoring, VA and CMT were similar at the time of fellow eye diagnosis for both groups.https://www.mdpi.com/2075-1729/13/2/385neovascular age-related macular degenerationanti-vascular endothelial growth factorchoroidal neovascularizationoptical coherence tomographyvisual acuity |
| spellingShingle | Oluchukwu Onwuka Jackson L. Saddemi Fatma Sema Akkan Aydoğmuş Claudia C. Lasalle David J. Ramsey Consequences of Real-World Surveillance of Fellow Eyes in Neovascular Age-Related Macular Degeneration Life neovascular age-related macular degeneration anti-vascular endothelial growth factor choroidal neovascularization optical coherence tomography visual acuity |
| title | Consequences of Real-World Surveillance of Fellow Eyes in Neovascular Age-Related Macular Degeneration |
| title_full | Consequences of Real-World Surveillance of Fellow Eyes in Neovascular Age-Related Macular Degeneration |
| title_fullStr | Consequences of Real-World Surveillance of Fellow Eyes in Neovascular Age-Related Macular Degeneration |
| title_full_unstemmed | Consequences of Real-World Surveillance of Fellow Eyes in Neovascular Age-Related Macular Degeneration |
| title_short | Consequences of Real-World Surveillance of Fellow Eyes in Neovascular Age-Related Macular Degeneration |
| title_sort | consequences of real world surveillance of fellow eyes in neovascular age related macular degeneration |
| topic | neovascular age-related macular degeneration anti-vascular endothelial growth factor choroidal neovascularization optical coherence tomography visual acuity |
| url | https://www.mdpi.com/2075-1729/13/2/385 |
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