Suppression of the HBP Function Increases Pancreatic Cancer Cell Sensitivity to a Pan-RAS Inhibitor

Suppression of the HBP Function Increases Pancreatic Cancer Cell Sensitivity to a Pan-RAS Inhibitor

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related death and the search for a resolutive therapy is still a challenge. Since KRAS is commonly mutated in PDAC and is one of the main drivers of PDAC progression, its inhibition should be a key strategy for treatment, especiall...

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Bibliographic Details
Main Authors: Francesca Ricciardiello, Laura Bergamaschi, Humberto De Vitto, Yang Gang, Taiping Zhang, Roberta Palorini, Ferdinando Chiaradonna
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
PDAC
hexosamine biosynthetic pathway
glycosylations
KRAS
KRAS inhibitors
cancer treatment
Online Access:https://www.mdpi.com/2073-4409/10/2/431

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