The effects of single and combined application of ramipril and losartan on renal structure and function in hypertensive rats
The objective of the present study was to investigate the effects of single and combined administration of ramipril and losartan on renal structure and function in spontaneously hypertensive rats (SHRs). Thirty-two 9-week-old SHRs and eight Wistar-Kyoto (WKY) rats were randomly divided into five gro...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-10-01
|
| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2017.1416118 |
| _version_ | 1797681408460718080 |
|---|---|
| author | Lin Yun Xingshun Xu Ying Dai Rui Xu Guohua Li Yucai Yao Jiamin Li Fei Zheng |
| author_facet | Lin Yun Xingshun Xu Ying Dai Rui Xu Guohua Li Yucai Yao Jiamin Li Fei Zheng |
| author_sort | Lin Yun |
| collection | DOAJ |
| description | The objective of the present study was to investigate the effects of single and combined administration of ramipril and losartan on renal structure and function in spontaneously hypertensive rats (SHRs). Thirty-two 9-week-old SHRs and eight Wistar-Kyoto (WKY) rats were randomly divided into five groups: the WKY control group, the SHR control group, the SHR-ramipril group, the SHR-losartan group, and the SHR-combined mediation group. The rat body weight, SBP, heart rate, and urinary albumin excretion rate (UAER) were measured. (1) The SBP was reduced to the normal level in all groups of rats except for the SHR control group. Combined administration of ramipril and losartan can be reduced to the normal level earlier than single (P < 0.01). (2) The SHR-ramipril group and the SHR-losartan group still experienced a higher UAER than that in the WKY control group (P < 0.01). (3) The renal mass/BW ratio was decreased in the SHR-ramipril group, SHR-losartan group, and SHR-combined medication group compared to that in the SHR control group (P < 0.01). (4) Compared with the SHR control group, the SHR-ramipril group, the SHR-losartan group, and the SHR-combined medication group had a lower percentage of the IOD of glomerular collagen relative to the glomerular area (P < 0.01). (5) The reduction in tubulointerstitial injury score was more significant in the SHR-combined medication group than in the SHR-ramipril group and the SHR-losartan group (P < 0.01). The combination of ramipril and losartan is superior to either single drug in reducing the UAER, resisting glomerular collagen deposition, and protecting renal tubular structure. |
| first_indexed | 2024-03-11T23:44:29Z |
| format | Article |
| id | doaj.art-ee414370706242eebc6ce78abb641c21 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:44:29Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-ee414370706242eebc6ce78abb641c212023-09-19T15:19:26ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062018-10-0140761762310.1080/10641963.2017.14161181416118The effects of single and combined application of ramipril and losartan on renal structure and function in hypertensive ratsLin Yun0Xingshun Xu1Ying Dai2Rui Xu3Guohua Li4Yucai Yao5Jiamin Li6Fei Zheng7Jinan Maternity and Child Care HospitalJinan Maternity and Child Care HospitalJinan Maternity and Child Care HospitalShandong UniversityShandong UniversityShandong UniversityShandong UniversityShandong UniversityThe objective of the present study was to investigate the effects of single and combined administration of ramipril and losartan on renal structure and function in spontaneously hypertensive rats (SHRs). Thirty-two 9-week-old SHRs and eight Wistar-Kyoto (WKY) rats were randomly divided into five groups: the WKY control group, the SHR control group, the SHR-ramipril group, the SHR-losartan group, and the SHR-combined mediation group. The rat body weight, SBP, heart rate, and urinary albumin excretion rate (UAER) were measured. (1) The SBP was reduced to the normal level in all groups of rats except for the SHR control group. Combined administration of ramipril and losartan can be reduced to the normal level earlier than single (P < 0.01). (2) The SHR-ramipril group and the SHR-losartan group still experienced a higher UAER than that in the WKY control group (P < 0.01). (3) The renal mass/BW ratio was decreased in the SHR-ramipril group, SHR-losartan group, and SHR-combined medication group compared to that in the SHR control group (P < 0.01). (4) Compared with the SHR control group, the SHR-ramipril group, the SHR-losartan group, and the SHR-combined medication group had a lower percentage of the IOD of glomerular collagen relative to the glomerular area (P < 0.01). (5) The reduction in tubulointerstitial injury score was more significant in the SHR-combined medication group than in the SHR-ramipril group and the SHR-losartan group (P < 0.01). The combination of ramipril and losartan is superior to either single drug in reducing the UAER, resisting glomerular collagen deposition, and protecting renal tubular structure.http://dx.doi.org/10.1080/10641963.2017.1416118spontaneously hypertensive raturine microalbuminramiprillosartanrenal damage |
| spellingShingle | Lin Yun Xingshun Xu Ying Dai Rui Xu Guohua Li Yucai Yao Jiamin Li Fei Zheng The effects of single and combined application of ramipril and losartan on renal structure and function in hypertensive rats Clinical and Experimental Hypertension spontaneously hypertensive rat urine microalbumin ramipril losartan renal damage |
| title | The effects of single and combined application of ramipril and losartan on renal structure and function in hypertensive rats |
| title_full | The effects of single and combined application of ramipril and losartan on renal structure and function in hypertensive rats |
| title_fullStr | The effects of single and combined application of ramipril and losartan on renal structure and function in hypertensive rats |
| title_full_unstemmed | The effects of single and combined application of ramipril and losartan on renal structure and function in hypertensive rats |
| title_short | The effects of single and combined application of ramipril and losartan on renal structure and function in hypertensive rats |
| title_sort | effects of single and combined application of ramipril and losartan on renal structure and function in hypertensive rats |
| topic | spontaneously hypertensive rat urine microalbumin ramipril losartan renal damage |
| url | http://dx.doi.org/10.1080/10641963.2017.1416118 |
| work_keys_str_mv | AT linyun theeffectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT xingshunxu theeffectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT yingdai theeffectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT ruixu theeffectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT guohuali theeffectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT yucaiyao theeffectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT jiaminli theeffectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT feizheng theeffectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT linyun effectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT xingshunxu effectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT yingdai effectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT ruixu effectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT guohuali effectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT yucaiyao effectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT jiaminli effectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats AT feizheng effectsofsingleandcombinedapplicationoframiprilandlosartanonrenalstructureandfunctioninhypertensiverats |