Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review
The accumulation of blood proteins and cells on extracorporeal membrane oxygenation (ECMO) circuits has been proposed as a contributing factor to the coagulopathic state of many patients. This systematic review aims to summarize and discuss the existing knowledge of blood components binding to the E...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/10/3272 |
| _version_ | 1797551249447452672 |
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| author | Sam Callaghan Tengyi Cai Conor McCafferty Suelyn Van Den Helm Steve Horton Graeme MacLaren Paul Monagle Vera Ignjatovic |
| author_facet | Sam Callaghan Tengyi Cai Conor McCafferty Suelyn Van Den Helm Steve Horton Graeme MacLaren Paul Monagle Vera Ignjatovic |
| author_sort | Sam Callaghan |
| collection | DOAJ |
| description | The accumulation of blood proteins and cells on extracorporeal membrane oxygenation (ECMO) circuits has been proposed as a contributing factor to the coagulopathic state of many patients. This systematic review aims to summarize and discuss the existing knowledge of blood components binding to the ECMO circuits in human patients. A systematic review was conducted using the Medline, PubMed and Embase databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Seven studies were included in this review. Three studies identified a leukocyte adhesion, three studies observed von Willebrand factor accumulation and four studies identified bound platelets on the surface of the circuits. Other identified components included fibrin, albumin, hemoglobin, erythrocytes, progenitor cells, fibronectin and IgG. This systematic review demonstrates the limited state of knowledge when it comes to adsorption to the ECMO circuits in humans. Most of the studies lacked insight or detail into the mechanisms of binding and the interactions between different components bound to the ECMO circuits. Further research is required to comprehensively characterize surface adsorption to ECMO circuits in humans and to define the specific mechanisms of binding, enabling improvements that increase biocompatibility between the blood-circuit interface in this important clinical setting. |
| first_indexed | 2024-03-10T15:41:54Z |
| format | Article |
| id | doaj.art-ee4307fc8f1d4bb99bf0b667b9e7b168 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T15:41:54Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ee4307fc8f1d4bb99bf0b667b9e7b1682023-11-20T16:47:26ZengMDPI AGJournal of Clinical Medicine2077-03832020-10-01910327210.3390/jcm9103272Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic ReviewSam Callaghan0Tengyi Cai1Conor McCafferty2Suelyn Van Den Helm3Steve Horton4Graeme MacLaren5Paul Monagle6Vera Ignjatovic7Department of Haematology Research, Murdoch Children’s Research Institute, MCRI, Parkville 3052, AustraliaDepartment of Haematology Research, Murdoch Children’s Research Institute, MCRI, Parkville 3052, AustraliaDepartment of Haematology Research, Murdoch Children’s Research Institute, MCRI, Parkville 3052, AustraliaDepartment of Haematology Research, Murdoch Children’s Research Institute, MCRI, Parkville 3052, AustraliaDepartment of Haematology Research, Murdoch Children’s Research Institute, MCRI, Parkville 3052, AustraliaDepartment of Haematology Research, Murdoch Children’s Research Institute, MCRI, Parkville 3052, AustraliaDepartment of Haematology Research, Murdoch Children’s Research Institute, MCRI, Parkville 3052, AustraliaDepartment of Haematology Research, Murdoch Children’s Research Institute, MCRI, Parkville 3052, AustraliaThe accumulation of blood proteins and cells on extracorporeal membrane oxygenation (ECMO) circuits has been proposed as a contributing factor to the coagulopathic state of many patients. This systematic review aims to summarize and discuss the existing knowledge of blood components binding to the ECMO circuits in human patients. A systematic review was conducted using the Medline, PubMed and Embase databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Seven studies were included in this review. Three studies identified a leukocyte adhesion, three studies observed von Willebrand factor accumulation and four studies identified bound platelets on the surface of the circuits. Other identified components included fibrin, albumin, hemoglobin, erythrocytes, progenitor cells, fibronectin and IgG. This systematic review demonstrates the limited state of knowledge when it comes to adsorption to the ECMO circuits in humans. Most of the studies lacked insight or detail into the mechanisms of binding and the interactions between different components bound to the ECMO circuits. Further research is required to comprehensively characterize surface adsorption to ECMO circuits in humans and to define the specific mechanisms of binding, enabling improvements that increase biocompatibility between the blood-circuit interface in this important clinical setting.https://www.mdpi.com/2077-0383/9/10/3272ECMOadsorptionmembrane oxygenatorcircuitbinding |
| spellingShingle | Sam Callaghan Tengyi Cai Conor McCafferty Suelyn Van Den Helm Steve Horton Graeme MacLaren Paul Monagle Vera Ignjatovic Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review Journal of Clinical Medicine ECMO adsorption membrane oxygenator circuit binding |
| title | Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review |
| title_full | Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review |
| title_fullStr | Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review |
| title_full_unstemmed | Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review |
| title_short | Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review |
| title_sort | adsorption of blood components to extracorporeal membrane oxygenation ecmo surfaces in humans a systematic review |
| topic | ECMO adsorption membrane oxygenator circuit binding |
| url | https://www.mdpi.com/2077-0383/9/10/3272 |
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