Association of Epstein-Barr virus with invasive breast carcinoma and its impact on well-known clinicopathologic parameters in Iranian women
Background: The association between Epstein-Barr virus (EBV) and breast carcinoma in Iranian women is uncertain. We examined EBV latent membrane protein-1 (LMP-1) antigen expression in breast carcinoma and its relationship with clinicopathologic parameters among a population of Iranian patients. Ma...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Advanced Biomedical Research |
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| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=141;epage=141;aulast=Mohammadizadeh |
| _version_ | 1818042470748913664 |
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| author | Fereshteh Mohammadizadeh Mojtaba Zarean Maryam Abbasi |
| author_facet | Fereshteh Mohammadizadeh Mojtaba Zarean Maryam Abbasi |
| author_sort | Fereshteh Mohammadizadeh |
| collection | DOAJ |
| description | Background: The association between Epstein-Barr virus (EBV) and breast carcinoma in Iranian women is uncertain. We examined EBV latent membrane protein-1 (LMP-1) antigen expression in breast carcinoma and its relationship with clinicopathologic parameters among a population of Iranian patients.
Materials and Methods: This study was performed on formalin fixed and paraffin embedded tissue specimens with a diagnosis of invasive breast carcinoma archived at one university hospital in Isfahan city, Iran. We used immunohistochemistry to detect LMP-1 of EBV in carcinoma and its adjacent normal tissue. The frequency of LMP-1 expression in breast carcinoma and its relationship with age, tumor size, tumor type, tumor grade and lymph node status were then determined.
Results: A total of 80 cases were evaluated including 77 (96.3%) ductal, 1 (1.3%) lobular, 1 (1.3%) medullary and 1 (1.3%) mucinous carcinoma. LMP-1 expression was seen in 6 cases (7.5%) of breast carcinoma whereas normal breast tissue adjacent to carcinoma was negative for LMP-1 in all of the cases. A statistically significant association was seen between EBV and invasive breast carcinoma (P = 0.03). No significant relationship was observed between LMP-1 expression on one hand and age, tumor size, tumor type, tumor grade and lymph node status on the other.
Conclusion: EBV may play an etiological role in some of the cases of breast carcinoma in Iranian women. EBV expression does not seem to have a significant impact on the major clinicopathologic prognostic determinants of breast carcinoma. |
| first_indexed | 2024-12-10T08:46:50Z |
| format | Article |
| id | doaj.art-ee44dcaa0b3847b98db70dbef62343c0 |
| institution | Directory Open Access Journal |
| issn | 2277-9175 2277-9175 |
| language | English |
| last_indexed | 2024-12-10T08:46:50Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-ee44dcaa0b3847b98db70dbef62343c02022-12-22T01:55:43ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752277-91752014-01-013114114110.4103/2277-9175.135158Association of Epstein-Barr virus with invasive breast carcinoma and its impact on well-known clinicopathologic parameters in Iranian womenFereshteh MohammadizadehMojtaba ZareanMaryam AbbasiBackground: The association between Epstein-Barr virus (EBV) and breast carcinoma in Iranian women is uncertain. We examined EBV latent membrane protein-1 (LMP-1) antigen expression in breast carcinoma and its relationship with clinicopathologic parameters among a population of Iranian patients. Materials and Methods: This study was performed on formalin fixed and paraffin embedded tissue specimens with a diagnosis of invasive breast carcinoma archived at one university hospital in Isfahan city, Iran. We used immunohistochemistry to detect LMP-1 of EBV in carcinoma and its adjacent normal tissue. The frequency of LMP-1 expression in breast carcinoma and its relationship with age, tumor size, tumor type, tumor grade and lymph node status were then determined. Results: A total of 80 cases were evaluated including 77 (96.3%) ductal, 1 (1.3%) lobular, 1 (1.3%) medullary and 1 (1.3%) mucinous carcinoma. LMP-1 expression was seen in 6 cases (7.5%) of breast carcinoma whereas normal breast tissue adjacent to carcinoma was negative for LMP-1 in all of the cases. A statistically significant association was seen between EBV and invasive breast carcinoma (P = 0.03). No significant relationship was observed between LMP-1 expression on one hand and age, tumor size, tumor type, tumor grade and lymph node status on the other. Conclusion: EBV may play an etiological role in some of the cases of breast carcinoma in Iranian women. EBV expression does not seem to have a significant impact on the major clinicopathologic prognostic determinants of breast carcinoma.http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=141;epage=141;aulast=MohammadizadehBreast carcinomaEpstein-Barr viruslatent membrane protein-1 antigen |
| spellingShingle | Fereshteh Mohammadizadeh Mojtaba Zarean Maryam Abbasi Association of Epstein-Barr virus with invasive breast carcinoma and its impact on well-known clinicopathologic parameters in Iranian women Advanced Biomedical Research Breast carcinoma Epstein-Barr virus latent membrane protein-1 antigen |
| title | Association of Epstein-Barr virus with invasive breast carcinoma and its impact on well-known clinicopathologic parameters in Iranian women |
| title_full | Association of Epstein-Barr virus with invasive breast carcinoma and its impact on well-known clinicopathologic parameters in Iranian women |
| title_fullStr | Association of Epstein-Barr virus with invasive breast carcinoma and its impact on well-known clinicopathologic parameters in Iranian women |
| title_full_unstemmed | Association of Epstein-Barr virus with invasive breast carcinoma and its impact on well-known clinicopathologic parameters in Iranian women |
| title_short | Association of Epstein-Barr virus with invasive breast carcinoma and its impact on well-known clinicopathologic parameters in Iranian women |
| title_sort | association of epstein barr virus with invasive breast carcinoma and its impact on well known clinicopathologic parameters in iranian women |
| topic | Breast carcinoma Epstein-Barr virus latent membrane protein-1 antigen |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=141;epage=141;aulast=Mohammadizadeh |
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