DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways

DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways

Abstract Background Gastric cancer (GC) is one of the most common malignancies worldwide, particularly in China. DNA damage-inducible transcript 4 (DDIT4) is a mammalian target of rapamycin inhibitor and is induced by various cellular stresses; however, its critical role in GC remains poorly underst...

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Bibliographic Details
Main Authors: Feng Du, Lina Sun, Yi Chu, Tingyu Li, Chao Lei, Xin Wang, Mingzuo Jiang, Yali Min, Yuanyuan Lu, Xiaodi Zhao, Yongzhan Nie, Daiming Fan
Format: Article
Language:English
Published: Wiley 2018-07-01
Series:Cancer Communications
Subjects:
DNA damage-inducible transcript 4
Gastric cancer
Proliferation
Mitogen-activated protein kinase
p53
Online Access:http://link.springer.com/article/10.1186/s40880-018-0315-y

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