Biodistribution and Imaging of The 99mTc-Glutathione Radiopharmaceutical in White Rats Induced with Cancer
99mTc-glutathione (99mTc-GSH) is a radiopharmaceutical which is potentially used as a cancer diagnostic kit. As with other radiopharmaceuticals, before applied in humans, including in clinical trials, 99mTc-GSH needs to go through a series of preclinical trials in animal first. The preclinical trial...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Center for Development of Nuclear Informatics, National Nuclear Energy Agency (BATAN)
2013-12-01
|
| Series: | Atom Indonesia |
| Subjects: | |
| Online Access: | http://aij.batan.go.id/index.php/aij/article/view/250 |
| _version_ | 1828446241111932928 |
|---|---|
| author | H. Wongso N. Zainuddin Iswahyudi |
| author_facet | H. Wongso N. Zainuddin Iswahyudi |
| author_sort | H. Wongso |
| collection | DOAJ |
| description | 99mTc-glutathione (99mTc-GSH) is a radiopharmaceutical which is potentially used as a cancer diagnostic kit. As with other radiopharmaceuticals, before applied in humans, including in clinical trials, 99mTc-GSH needs to go through a series of preclinical trials in animal first. The preclinical trial which has been done in this study is the evaluation of the biological test on biodistribution and imaging of white rats (Rattus norvegicus) which had been induced with cancer. The aims of this research were to obtain data on biodistribution and to image the biodistribution of 99mTc-GSH at 1 hour, 3 hours, and 24 hours post-injection. Biodistribution results of 99mTc-GSH in the cancer at the times of 1 hour, 3 hours, and 24 hours after injection were 0.66% ID/g, 0.95% ID/g, and 0.06% ID/g, respectively. This result shows that the highest accumulation of 99mTc-GSH in cancer occur at 3 hours post-injection. This value indicates that the optimal accumulation of the 99mTc-GSH occur in this time interval. In addition, the results of imaging test also show that the accumulation capacity of 99mTc-GSH in cancer is also highest at 3 hours post-injection. |
| first_indexed | 2024-12-10T22:09:18Z |
| format | Article |
| id | doaj.art-ee4873440acd499f8b442561e0d4f374 |
| institution | Directory Open Access Journal |
| issn | 0126-1568 |
| language | English |
| last_indexed | 2024-12-10T22:09:18Z |
| publishDate | 2013-12-01 |
| publisher | Center for Development of Nuclear Informatics, National Nuclear Energy Agency (BATAN) |
| record_format | Article |
| series | Atom Indonesia |
| spelling | doaj.art-ee4873440acd499f8b442561e0d4f3742022-12-22T01:31:40ZengCenter for Development of Nuclear Informatics, National Nuclear Energy Agency (BATAN)Atom Indonesia0126-15682013-12-01393106111Biodistribution and Imaging of The 99mTc-Glutathione Radiopharmaceutical in White Rats Induced with CancerH. WongsoN. ZainuddinIswahyudi99mTc-glutathione (99mTc-GSH) is a radiopharmaceutical which is potentially used as a cancer diagnostic kit. As with other radiopharmaceuticals, before applied in humans, including in clinical trials, 99mTc-GSH needs to go through a series of preclinical trials in animal first. The preclinical trial which has been done in this study is the evaluation of the biological test on biodistribution and imaging of white rats (Rattus norvegicus) which had been induced with cancer. The aims of this research were to obtain data on biodistribution and to image the biodistribution of 99mTc-GSH at 1 hour, 3 hours, and 24 hours post-injection. Biodistribution results of 99mTc-GSH in the cancer at the times of 1 hour, 3 hours, and 24 hours after injection were 0.66% ID/g, 0.95% ID/g, and 0.06% ID/g, respectively. This result shows that the highest accumulation of 99mTc-GSH in cancer occur at 3 hours post-injection. This value indicates that the optimal accumulation of the 99mTc-GSH occur in this time interval. In addition, the results of imaging test also show that the accumulation capacity of 99mTc-GSH in cancer is also highest at 3 hours post-injection.http://aij.batan.go.id/index.php/aij/article/view/25099mTc-glutathioneBiodistributionImagingCancer |
| spellingShingle | H. Wongso N. Zainuddin Iswahyudi Biodistribution and Imaging of The 99mTc-Glutathione Radiopharmaceutical in White Rats Induced with Cancer Atom Indonesia 99mTc-glutathione Biodistribution Imaging Cancer |
| title | Biodistribution and Imaging of The 99mTc-Glutathione Radiopharmaceutical in White Rats Induced with Cancer |
| title_full | Biodistribution and Imaging of The 99mTc-Glutathione Radiopharmaceutical in White Rats Induced with Cancer |
| title_fullStr | Biodistribution and Imaging of The 99mTc-Glutathione Radiopharmaceutical in White Rats Induced with Cancer |
| title_full_unstemmed | Biodistribution and Imaging of The 99mTc-Glutathione Radiopharmaceutical in White Rats Induced with Cancer |
| title_short | Biodistribution and Imaging of The 99mTc-Glutathione Radiopharmaceutical in White Rats Induced with Cancer |
| title_sort | biodistribution and imaging of the 99mtc glutathione radiopharmaceutical in white rats induced with cancer |
| topic | 99mTc-glutathione Biodistribution Imaging Cancer |
| url | http://aij.batan.go.id/index.php/aij/article/view/250 |
| work_keys_str_mv | AT hwongso biodistributionandimagingofthe99mtcglutathioneradiopharmaceuticalinwhiteratsinducedwithcancer AT nzainuddin biodistributionandimagingofthe99mtcglutathioneradiopharmaceuticalinwhiteratsinducedwithcancer AT iswahyudi biodistributionandimagingofthe99mtcglutathioneradiopharmaceuticalinwhiteratsinducedwithcancer |