| Summary: | Lactic acid bacteria exhibit antitumor effects in mouse models of cancer. However, the effects of lactic acid bacteria on cancer remain unknown. This study investigated its effect in a mouse model of chronic inflammation-associated colon cancer induced by azoxymethane (AOM) and dextran sodium sulfate (DSS). Administration of Bacillus coagulans ameliorated AOM+DSS-induced colon cancer in mice. B. coagulans increased the expression of transforming growth factor (TGF)-β, mothers against decapentaplegic homolog (Smad) 2/3, and p21, a cyclin-dependent kinase inhibitor (CDKI); and decreased that of the c-myelocytomatosis oncogene product (c-Myc). Furthermore, reductions in phosphatidylinositol-3 kinase (PI3K), phospho-protein kinase B (pAKT), and mechanistic target of rapamycin (mTOR) levels were observed after B. coagulans administration. Additionally, increased I kappa B (IκB) and decreased interleukin (IL)-6 and interferon (IFN)-γ levels were detected. The ameliorating effect of B. coagulans on colon cancer may be induced by the combined actions of TGF-β/Smad2/3/p21・C-Myc, PI3K/AKT/mTOR, and IκB/IL-6・IFN-γ.
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