Bacillus coagulans (species of lactic acid-forming Bacillus bacteria) ameliorates azoxymethane and dextran sodium sulfate-induced colon cancer in mice
Lactic acid bacteria exhibit antitumor effects in mouse models of cancer. However, the effects of lactic acid bacteria on cancer remain unknown. This study investigated its effect in a mouse model of chronic inflammation-associated colon cancer induced by azoxymethane (AOM) and dextran sodium sulfat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623000063 |
| _version_ | 1797956274997952512 |
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| author | Keiichi Hiramoto Sayaka Kubo Keiko Tsuji Daijiro Sugiyama Yasutaka Iizuka Hideo Hamano |
| author_facet | Keiichi Hiramoto Sayaka Kubo Keiko Tsuji Daijiro Sugiyama Yasutaka Iizuka Hideo Hamano |
| author_sort | Keiichi Hiramoto |
| collection | DOAJ |
| description | Lactic acid bacteria exhibit antitumor effects in mouse models of cancer. However, the effects of lactic acid bacteria on cancer remain unknown. This study investigated its effect in a mouse model of chronic inflammation-associated colon cancer induced by azoxymethane (AOM) and dextran sodium sulfate (DSS). Administration of Bacillus coagulans ameliorated AOM+DSS-induced colon cancer in mice. B. coagulans increased the expression of transforming growth factor (TGF)-β, mothers against decapentaplegic homolog (Smad) 2/3, and p21, a cyclin-dependent kinase inhibitor (CDKI); and decreased that of the c-myelocytomatosis oncogene product (c-Myc). Furthermore, reductions in phosphatidylinositol-3 kinase (PI3K), phospho-protein kinase B (pAKT), and mechanistic target of rapamycin (mTOR) levels were observed after B. coagulans administration. Additionally, increased I kappa B (IκB) and decreased interleukin (IL)-6 and interferon (IFN)-γ levels were detected. The ameliorating effect of B. coagulans on colon cancer may be induced by the combined actions of TGF-β/Smad2/3/p21・C-Myc, PI3K/AKT/mTOR, and IκB/IL-6・IFN-γ. |
| first_indexed | 2024-04-10T23:46:27Z |
| format | Article |
| id | doaj.art-ee491a94660b4de1a1c16561eab73335 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-10T23:46:27Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-ee491a94660b4de1a1c16561eab733352023-01-11T04:28:23ZengElsevierJournal of Functional Foods1756-46462023-01-01100105406Bacillus coagulans (species of lactic acid-forming Bacillus bacteria) ameliorates azoxymethane and dextran sodium sulfate-induced colon cancer in miceKeiichi Hiramoto0Sayaka Kubo1Keiko Tsuji2Daijiro Sugiyama3Yasutaka Iizuka4Hideo Hamano5Department of Pharmaceutical Science, Suzuka University of Medical Science, Mie 513-8670, Japan; Corresponding author at: Department of Pharmaceutical Science, Suzuka University of Medical Science, 3500-3 Minamitamagakicho, Suzuka, Mie 513-8670, Japan.R&D Department, Daiichi Sankyo Healthcare Co., Ltd. Chuo-ku, Tokyo 103-8234, JapanR&D Department, Daiichi Sankyo Healthcare Co., Ltd. Chuo-ku, Tokyo 103-8234, JapanR&D Department, Daiichi Sankyo Healthcare Co., Ltd. Chuo-ku, Tokyo 103-8234, JapanR&D Department, Daiichi Sankyo Healthcare Co., Ltd. Chuo-ku, Tokyo 103-8234, JapanR&D Department, Daiichi Sankyo Healthcare Co., Ltd. Chuo-ku, Tokyo 103-8234, JapanLactic acid bacteria exhibit antitumor effects in mouse models of cancer. However, the effects of lactic acid bacteria on cancer remain unknown. This study investigated its effect in a mouse model of chronic inflammation-associated colon cancer induced by azoxymethane (AOM) and dextran sodium sulfate (DSS). Administration of Bacillus coagulans ameliorated AOM+DSS-induced colon cancer in mice. B. coagulans increased the expression of transforming growth factor (TGF)-β, mothers against decapentaplegic homolog (Smad) 2/3, and p21, a cyclin-dependent kinase inhibitor (CDKI); and decreased that of the c-myelocytomatosis oncogene product (c-Myc). Furthermore, reductions in phosphatidylinositol-3 kinase (PI3K), phospho-protein kinase B (pAKT), and mechanistic target of rapamycin (mTOR) levels were observed after B. coagulans administration. Additionally, increased I kappa B (IκB) and decreased interleukin (IL)-6 and interferon (IFN)-γ levels were detected. The ameliorating effect of B. coagulans on colon cancer may be induced by the combined actions of TGF-β/Smad2/3/p21・C-Myc, PI3K/AKT/mTOR, and IκB/IL-6・IFN-γ.http://www.sciencedirect.com/science/article/pii/S1756464623000063B. coagulansTGF-βSmad2/3PI3KIκB |
| spellingShingle | Keiichi Hiramoto Sayaka Kubo Keiko Tsuji Daijiro Sugiyama Yasutaka Iizuka Hideo Hamano Bacillus coagulans (species of lactic acid-forming Bacillus bacteria) ameliorates azoxymethane and dextran sodium sulfate-induced colon cancer in mice Journal of Functional Foods B. coagulans TGF-β Smad2/3 PI3K IκB |
| title | Bacillus coagulans (species of lactic acid-forming Bacillus bacteria) ameliorates azoxymethane and dextran sodium sulfate-induced colon cancer in mice |
| title_full | Bacillus coagulans (species of lactic acid-forming Bacillus bacteria) ameliorates azoxymethane and dextran sodium sulfate-induced colon cancer in mice |
| title_fullStr | Bacillus coagulans (species of lactic acid-forming Bacillus bacteria) ameliorates azoxymethane and dextran sodium sulfate-induced colon cancer in mice |
| title_full_unstemmed | Bacillus coagulans (species of lactic acid-forming Bacillus bacteria) ameliorates azoxymethane and dextran sodium sulfate-induced colon cancer in mice |
| title_short | Bacillus coagulans (species of lactic acid-forming Bacillus bacteria) ameliorates azoxymethane and dextran sodium sulfate-induced colon cancer in mice |
| title_sort | bacillus coagulans species of lactic acid forming bacillus bacteria ameliorates azoxymethane and dextran sodium sulfate induced colon cancer in mice |
| topic | B. coagulans TGF-β Smad2/3 PI3K IκB |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623000063 |
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