Maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infants
Background: The reliable assessment of iron deficiency (ID) and the iron parameters which contribute to anaemia in preterm and term infants are of vital importance. Aim of the study: This study focuses on identifying maternal and cord blood hepcidin [Hep (CB)] levels based on gestational weeks (GW)...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-08-01
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| Series: | Pediatric Hematology Oncology Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S246812451630033X |
| _version_ | 1811262267261452288 |
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| author | Tamer Gunes Songul Yildirim Ahmet Ozdemir Selma Gokahmetoglu Sabriye Korkut Mehmet Adnan Ozturk Selim Kurtoglu |
| author_facet | Tamer Gunes Songul Yildirim Ahmet Ozdemir Selma Gokahmetoglu Sabriye Korkut Mehmet Adnan Ozturk Selim Kurtoglu |
| author_sort | Tamer Gunes |
| collection | DOAJ |
| description | Background: The reliable assessment of iron deficiency (ID) and the iron parameters which contribute to anaemia in preterm and term infants are of vital importance.
Aim of the study: This study focuses on identifying maternal and cord blood hepcidin [Hep (CB)] levels based on gestational weeks (GW) and comparing them with other parameters in iron metabolism.
Patients & methods: This is a prospective and observational study including 102 pregnant women and their infants. Along with Hep(CB), iron, iron chelation capacity, ferritin, transferrin saturation, C-reactive protein level were recorded for mothers and infants.
Results: Maternal and cord blood hepcidin levels were 135.0 ng/ml (6.40–2846.0) and 286.30 ng/ml (90–1697) for those under 33 GW (n = 27), 66.4 ng/ml (11.0–3936.0) and 406.9 ng/ml (10.0–1867) for those between 33 and 37 GW (n = 33), 41.4 ng/ml (2.8–513.7) and 498.1 ng/ml (343.7–701.7) for those over 37 GW (n = 42), respectively. Hep(CB) [104.7 ng/ml (5.0–1022.0), n = 22] levels were lower for infants with ID compared to those without iron deficiency [463.3 ng/ml (131.3–2261.0), p < 0.0001, n = 80)]. While a strongly positive relationship was observed between Hep(CB) levels and cord blood ferritin levels (Rho = 0.76, p < 0.0001) in the correlation analysis, a weak relationship (Rho = 0.29, p = 0.004) was found for transferrin saturation. Additionally, it was observed that Hep(CB) levels were directly proportional to GW (Rho = 0.23, p < 0.0001) and birth weight (Rho = 0.21, p = 0.03). A decrease of 10 units in Hep(CB) level increases risk for ID anaemia by 5% [OR = 0.95 (0.9297–0.98099)].
Conclusions: This study, which compares Hep(CB) levels and iron parameters based on GWs, differs from similar studies in terms of assessment of both preterm and term groups along with maternal levels. It is evident that increase in hepcidin prevents ID anaemia. |
| first_indexed | 2024-04-12T19:22:10Z |
| format | Article |
| id | doaj.art-ee4ad511308f4ab0a3c22d96ff016575 |
| institution | Directory Open Access Journal |
| issn | 2468-1245 |
| language | English |
| last_indexed | 2024-04-12T19:22:10Z |
| publishDate | 2016-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatric Hematology Oncology Journal |
| spelling | doaj.art-ee4ad511308f4ab0a3c22d96ff0165752022-12-22T03:19:34ZengElsevierPediatric Hematology Oncology Journal2468-12452016-08-0112232710.1016/j.phoj.2016.07.007Maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infantsTamer Gunes0Songul Yildirim1Ahmet Ozdemir2Selma Gokahmetoglu3Sabriye Korkut4Mehmet Adnan Ozturk5Selim Kurtoglu6Division of Neonatalogy, Department of Pediatrics, Erciyes University, Faculty of Medicine, 38039, Kayseri, TurkeyDepartment of Pediatrics, Erciyes University, Faculty of Medicine, Talas Street, 38039, Kayseri, TurkeyDivision of Neonatalogy, Department of Pediatrics, Erciyes University, Faculty of Medicine, 38039, Kayseri, TurkeyDepartment of Medical Microbiology, Erciyes University, Faculty of Medicine, 38039, Kayseri, TurkeyDivision of Neonatalogy, Department of Pediatrics, Erciyes University, Faculty of Medicine, 38039, Kayseri, TurkeyDivision of Neonatalogy, Department of Pediatrics, Erciyes University, Faculty of Medicine, 38039, Kayseri, TurkeyDivision of Neonatalogy, Department of Pediatrics, Erciyes University, Faculty of Medicine, 38039, Kayseri, TurkeyBackground: The reliable assessment of iron deficiency (ID) and the iron parameters which contribute to anaemia in preterm and term infants are of vital importance. Aim of the study: This study focuses on identifying maternal and cord blood hepcidin [Hep (CB)] levels based on gestational weeks (GW) and comparing them with other parameters in iron metabolism. Patients & methods: This is a prospective and observational study including 102 pregnant women and their infants. Along with Hep(CB), iron, iron chelation capacity, ferritin, transferrin saturation, C-reactive protein level were recorded for mothers and infants. Results: Maternal and cord blood hepcidin levels were 135.0 ng/ml (6.40–2846.0) and 286.30 ng/ml (90–1697) for those under 33 GW (n = 27), 66.4 ng/ml (11.0–3936.0) and 406.9 ng/ml (10.0–1867) for those between 33 and 37 GW (n = 33), 41.4 ng/ml (2.8–513.7) and 498.1 ng/ml (343.7–701.7) for those over 37 GW (n = 42), respectively. Hep(CB) [104.7 ng/ml (5.0–1022.0), n = 22] levels were lower for infants with ID compared to those without iron deficiency [463.3 ng/ml (131.3–2261.0), p < 0.0001, n = 80)]. While a strongly positive relationship was observed between Hep(CB) levels and cord blood ferritin levels (Rho = 0.76, p < 0.0001) in the correlation analysis, a weak relationship (Rho = 0.29, p = 0.004) was found for transferrin saturation. Additionally, it was observed that Hep(CB) levels were directly proportional to GW (Rho = 0.23, p < 0.0001) and birth weight (Rho = 0.21, p = 0.03). A decrease of 10 units in Hep(CB) level increases risk for ID anaemia by 5% [OR = 0.95 (0.9297–0.98099)]. Conclusions: This study, which compares Hep(CB) levels and iron parameters based on GWs, differs from similar studies in terms of assessment of both preterm and term groups along with maternal levels. It is evident that increase in hepcidin prevents ID anaemia.http://www.sciencedirect.com/science/article/pii/S246812451630033XCord bloodFerritinGestational weekHepcidinIron metabolism |
| spellingShingle | Tamer Gunes Songul Yildirim Ahmet Ozdemir Selma Gokahmetoglu Sabriye Korkut Mehmet Adnan Ozturk Selim Kurtoglu Maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infants Pediatric Hematology Oncology Journal Cord blood Ferritin Gestational week Hepcidin Iron metabolism |
| title | Maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infants |
| title_full | Maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infants |
| title_fullStr | Maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infants |
| title_full_unstemmed | Maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infants |
| title_short | Maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infants |
| title_sort | maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infants |
| topic | Cord blood Ferritin Gestational week Hepcidin Iron metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S246812451630033X |
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