Metabolic Engineering of Saccharomyces cerevisiae for Heterologous Carnosic Acid Production

Metabolic Engineering of Saccharomyces cerevisiae for Heterologous Carnosic Acid Production

Carnosic acid (CA), a phenolic tricyclic diterpene, has many biological effects, including anti-inflammatory, anticancer, antiobesity, and antidiabetic activities. In this study, an efficient biosynthetic pathway was constructed to produce CA in Saccharomyces cerevisiae. First, the CA precursor milt...

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Bibliographic Details
Main Authors: Panpan Wei, Chuanbo Zhang, Xueke Bian, Wenyu Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
carnosic acid
Saccharomyces cerevisiae
terpenoid
miltiradiene
synthetic biology
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.916605/full

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