Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells during human hookworm infection modulates antigen-mediated lymphocyte proliferation.

Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells during human hookworm infection modulates antigen-mediated lymphocyte proliferation.

Hookworm infection is considered one of the most important poverty-promoting neglected tropical diseases, infecting 576 to 740 million people worldwide, especially in the tropics and subtropics. These blood-feeding nematodes have a remarkable ability to downmodulate the host immune response, protect...

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Bibliographic Details
Main Authors: Natasha Delaqua Ricci, Jacqueline Araújo Fiúza, Lilian Lacerda Bueno, Guilherme Grossi Lopes Cançado, Pedro Henrique Gazzinelli-Guimarães, Virgillio Gandra Martins, Leonardo Ferreira Matoso, Rodrigo Rodrigues Cambraia de Miranda, Stefan Michael Geiger, Rodrigo Correa-Oliveira, Andréa Gazzinelli, Daniella Castanheira Bartholomeu, Ricardo Toshio Fujiwara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-11-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3210756?pdf=render

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