Smart MXene Quantum Dot-Based Nanosystems for Biomedical Applications
MXene quantum dots (QDs), with their unique structural, optical, magnetic, and electronic characteristics, are promising contenders for various pharmaceutical and biomedical appliances including biological sensing/imaging, cancer diagnosis/therapy, regenerative medicine, tissue engineering, delivery...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
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| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/12/7/1200 |
| _version_ | 1827622853323784192 |
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| author | Siavash Iravani Rajender S. Varma |
| author_facet | Siavash Iravani Rajender S. Varma |
| author_sort | Siavash Iravani |
| collection | DOAJ |
| description | MXene quantum dots (QDs), with their unique structural, optical, magnetic, and electronic characteristics, are promising contenders for various pharmaceutical and biomedical appliances including biological sensing/imaging, cancer diagnosis/therapy, regenerative medicine, tissue engineering, delivery of drugs/genes, and analytical biochemistry. Although functionalized MXene QDs have demonstrated high biocompatibility, superb optical properties, and stability, several challenging issues pertaining to their long-term toxicity, histopathology, biodistribution, biodegradability, and photoluminescence properties are still awaiting systematic study (especially the move towards the practical and clinical phases from the pre-clinical/lab-scale discoveries). The up-scalable and optimized synthesis methods need to be developed not only for the MXene QD-based nanosystems but also for other smart platforms and hybrid nanocomposites encompassing MXenes with vast clinical and biomedical potentials. Enhancing the functionalization strategies, improvement of synthesis methods, cytotoxicity/biosafety evaluations, enriching the biomedical applications, and exploring additional MXene QDs are crucial aspects for developing the smart MXene QD-based nanosystems with improved features. Herein, recent developments concerning the biomedical applications of MXene QDs are underscored with emphasis on current trends and future prospects. |
| first_indexed | 2024-03-09T11:34:01Z |
| format | Article |
| id | doaj.art-ee4bf87b0632497ba1f71915150fd0be |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T11:34:01Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-ee4bf87b0632497ba1f71915150fd0be2023-11-30T23:45:55ZengMDPI AGNanomaterials2079-49912022-04-01127120010.3390/nano12071200Smart MXene Quantum Dot-Based Nanosystems for Biomedical ApplicationsSiavash Iravani0Rajender S. Varma1Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, IranRegional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Šlechtitelů 27, 783 71 Olomouc, Czech RepublicMXene quantum dots (QDs), with their unique structural, optical, magnetic, and electronic characteristics, are promising contenders for various pharmaceutical and biomedical appliances including biological sensing/imaging, cancer diagnosis/therapy, regenerative medicine, tissue engineering, delivery of drugs/genes, and analytical biochemistry. Although functionalized MXene QDs have demonstrated high biocompatibility, superb optical properties, and stability, several challenging issues pertaining to their long-term toxicity, histopathology, biodistribution, biodegradability, and photoluminescence properties are still awaiting systematic study (especially the move towards the practical and clinical phases from the pre-clinical/lab-scale discoveries). The up-scalable and optimized synthesis methods need to be developed not only for the MXene QD-based nanosystems but also for other smart platforms and hybrid nanocomposites encompassing MXenes with vast clinical and biomedical potentials. Enhancing the functionalization strategies, improvement of synthesis methods, cytotoxicity/biosafety evaluations, enriching the biomedical applications, and exploring additional MXene QDs are crucial aspects for developing the smart MXene QD-based nanosystems with improved features. Herein, recent developments concerning the biomedical applications of MXene QDs are underscored with emphasis on current trends and future prospects.https://www.mdpi.com/2079-4991/12/7/1200MXenesMXene quantum dotsbiocompatibilitytoxicitysmart nanosystemsbiomedical applications |
| spellingShingle | Siavash Iravani Rajender S. Varma Smart MXene Quantum Dot-Based Nanosystems for Biomedical Applications Nanomaterials MXenes MXene quantum dots biocompatibility toxicity smart nanosystems biomedical applications |
| title | Smart MXene Quantum Dot-Based Nanosystems for Biomedical Applications |
| title_full | Smart MXene Quantum Dot-Based Nanosystems for Biomedical Applications |
| title_fullStr | Smart MXene Quantum Dot-Based Nanosystems for Biomedical Applications |
| title_full_unstemmed | Smart MXene Quantum Dot-Based Nanosystems for Biomedical Applications |
| title_short | Smart MXene Quantum Dot-Based Nanosystems for Biomedical Applications |
| title_sort | smart mxene quantum dot based nanosystems for biomedical applications |
| topic | MXenes MXene quantum dots biocompatibility toxicity smart nanosystems biomedical applications |
| url | https://www.mdpi.com/2079-4991/12/7/1200 |
| work_keys_str_mv | AT siavashiravani smartmxenequantumdotbasednanosystemsforbiomedicalapplications AT rajendersvarma smartmxenequantumdotbasednanosystemsforbiomedicalapplications |