School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits.
School-located influenza vaccination (SLIV) programs can substantially enhance the sub-optimal coverage achieved under existing delivery strategies. Randomized SLIV trials have shown these programs reduce laboratory-confirmed influenza among both vaccinated and unvaccinated children. This work explo...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4260868?pdf=render |
| _version_ | 1818178175277989888 |
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| author | Cuc H Tran Jonathan D Sugimoto Juliet R C Pulliam Kathleen A Ryan Paul D Myers Joan B Castleman Randell Doty Jackie Johnson Jim Stringfellow Nadia Kovacevich Joe Brew Lai Ling Cheung Brad Caron Gloria Lipori Christopher A Harle Charles Alexander Yang Yang Ira M Longini M Elizabeth Halloran J Glenn Morris Parker A Small |
| author_facet | Cuc H Tran Jonathan D Sugimoto Juliet R C Pulliam Kathleen A Ryan Paul D Myers Joan B Castleman Randell Doty Jackie Johnson Jim Stringfellow Nadia Kovacevich Joe Brew Lai Ling Cheung Brad Caron Gloria Lipori Christopher A Harle Charles Alexander Yang Yang Ira M Longini M Elizabeth Halloran J Glenn Morris Parker A Small |
| author_sort | Cuc H Tran |
| collection | DOAJ |
| description | School-located influenza vaccination (SLIV) programs can substantially enhance the sub-optimal coverage achieved under existing delivery strategies. Randomized SLIV trials have shown these programs reduce laboratory-confirmed influenza among both vaccinated and unvaccinated children. This work explores the effectiveness of a SLIV program in reducing the community risk of influenza and influenza-like illness (ILI) associated emergency care visits.For the 2011/12 and 2012/13 influenza seasons, we estimated age-group specific attack rates (AR) for ILI from routine surveillance and census data. Age-group specific SLIV program effectiveness was estimated as one minus the AR ratio for Alachua County versus two comparison regions: the 12 county region surrounding Alachua County, and all non-Alachua counties in Florida.Vaccination of ∼50% of 5-17 year-olds in Alachua reduced their risk of ILI-associated visits, compared to the rest of Florida, by 79% (95% confidence interval: 70, 85) in 2011/12 and 71% (63, 77) in 2012/13. The greatest indirect effectiveness was observed among 0-4 year-olds, reducing AR by 89% (84, 93) in 2011/12 and 84% (79, 88) in 2012/13. Among all non-school age residents, the estimated indirect effectiveness was 60% (54, 65) and 36% (31, 41) for 2011/12 and 2012/13. The overall effectiveness among all age-groups was 65% (61, 70) and 46% (42, 50) for 2011/12 and 2012/13.Wider implementation of SLIV programs can significantly reduce the influenza-associated public health burden in communities. |
| first_indexed | 2024-12-11T20:43:48Z |
| format | Article |
| id | doaj.art-ee4d63a94320420289bab188eebc159a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T20:43:48Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ee4d63a94320420289bab188eebc159a2022-12-22T00:51:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11447910.1371/journal.pone.0114479School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits.Cuc H TranJonathan D SugimotoJuliet R C PulliamKathleen A RyanPaul D MyersJoan B CastlemanRandell DotyJackie JohnsonJim StringfellowNadia KovacevichJoe BrewLai Ling CheungBrad CaronGloria LiporiChristopher A HarleCharles AlexanderYang YangIra M LonginiM Elizabeth HalloranJ Glenn MorrisParker A SmallSchool-located influenza vaccination (SLIV) programs can substantially enhance the sub-optimal coverage achieved under existing delivery strategies. Randomized SLIV trials have shown these programs reduce laboratory-confirmed influenza among both vaccinated and unvaccinated children. This work explores the effectiveness of a SLIV program in reducing the community risk of influenza and influenza-like illness (ILI) associated emergency care visits.For the 2011/12 and 2012/13 influenza seasons, we estimated age-group specific attack rates (AR) for ILI from routine surveillance and census data. Age-group specific SLIV program effectiveness was estimated as one minus the AR ratio for Alachua County versus two comparison regions: the 12 county region surrounding Alachua County, and all non-Alachua counties in Florida.Vaccination of ∼50% of 5-17 year-olds in Alachua reduced their risk of ILI-associated visits, compared to the rest of Florida, by 79% (95% confidence interval: 70, 85) in 2011/12 and 71% (63, 77) in 2012/13. The greatest indirect effectiveness was observed among 0-4 year-olds, reducing AR by 89% (84, 93) in 2011/12 and 84% (79, 88) in 2012/13. Among all non-school age residents, the estimated indirect effectiveness was 60% (54, 65) and 36% (31, 41) for 2011/12 and 2012/13. The overall effectiveness among all age-groups was 65% (61, 70) and 46% (42, 50) for 2011/12 and 2012/13.Wider implementation of SLIV programs can significantly reduce the influenza-associated public health burden in communities.http://europepmc.org/articles/PMC4260868?pdf=render |
| spellingShingle | Cuc H Tran Jonathan D Sugimoto Juliet R C Pulliam Kathleen A Ryan Paul D Myers Joan B Castleman Randell Doty Jackie Johnson Jim Stringfellow Nadia Kovacevich Joe Brew Lai Ling Cheung Brad Caron Gloria Lipori Christopher A Harle Charles Alexander Yang Yang Ira M Longini M Elizabeth Halloran J Glenn Morris Parker A Small School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits. PLoS ONE |
| title | School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits. |
| title_full | School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits. |
| title_fullStr | School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits. |
| title_full_unstemmed | School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits. |
| title_short | School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits. |
| title_sort | school located influenza vaccination reduces community risk for influenza and influenza like illness emergency care visits |
| url | http://europepmc.org/articles/PMC4260868?pdf=render |
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