Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells

Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells

Abstract Background We previously reported higher plasma levels of complement fragments C3a and C5a in neovascular Age-related Macular Degeneration (nAMD) patients with macular fibrosis. This study aimed to understand whether complement activation contributes to the development of macular fibrosis a...

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Bibliographic Details
Main Authors: María Llorián-Salvador, Eimear M. Byrne, Manon Szczepan, Karis Little, Mei Chen, Heping Xu
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Neuroinflammation
Subjects:
Age-related macular degeneration
Macular fibrosis
Inflammation
Complement system
Retinal pigment epithelial cell
C5a
Online Access:https://doi.org/10.1186/s12974-022-02546-3

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