RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS
The relationship between various subpopulations of regulatory T-cells (Treg) and serum level of CA-125 and dynamics of Treg following surgery in ovarian cancer (OC) patients have been investigated. The typical for OC peripheral blood Treg changes (the enchantment of CD4+FoxP3+ и CD8+FoxP3+ T-cells a...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/134 |
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| author | E. R. Chernykh E. V. Kurganova M. A. Tikhonova E. G. Laskavaya V. A. Lebedeva A. A. Ostanin |
| author_facet | E. R. Chernykh E. V. Kurganova M. A. Tikhonova E. G. Laskavaya V. A. Lebedeva A. A. Ostanin |
| author_sort | E. R. Chernykh |
| collection | DOAJ |
| description | The relationship between various subpopulations of regulatory T-cells (Treg) and serum level of CA-125 and dynamics of Treg following surgery in ovarian cancer (OC) patients have been investigated. The typical for OC peripheral blood Treg changes (the enchantment of CD4+FoxP3+ и CD8+FoxP3+ T-cells and decrease of CD4+CD25+/CD4+CD25high Т-cells due to their migration to ascites) have been revealed only in patients with elevated CA-125 level and were not registered in patient's group with normal level of this antigen. CA-125 serum level was directly correlated to absolute count of CD4+CD25high Т-cells and was in reverse relation to CD8+FoxP3+ T-cells. Surgical removal of a tumor was accompanied by remarkable reduction of CA-125 level in all cases. However Treg changes were observed only in patients with optimal cytoreductive surgery and were evidenced by CD4+CD25+/CD4+CD25high Т-cell normalization, whereas the number of these cells in peripheral blood of patients with residual tumors after surgery remained decreased. At that percentage of CD4+FoxP3+ и CD8+FoxP3+ Т-cells 2 weeks after surgery was unchanged and their increased number was associated with persisted decrease of T-cell proliferation in response to anti-CD3 stimulation. |
| first_indexed | 2024-03-08T05:52:08Z |
| format | Article |
| id | doaj.art-ee4f25e7fee0475e935f4f2374dddcec |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:21:42Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-ee4f25e7fee0475e935f4f2374dddcec2025-03-11T17:59:00ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01124-531131810.15789/1563-0625-2010-4-5-311-318131RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTSE. R. Chernykh0E. V. Kurganova1M. A. Tikhonova2E. G. Laskavaya3V. A. Lebedeva4A. A. Ostanin5НИИ клинической иммунологии СО РАМН, г. НовосибирскНИИ клинической иммунологии СО РАМН, г. НовосибирскНИИ клинической иммунологии СО РАМН, г. НовосибирскГородская муниципальная клиническая больница № 1, г. НовосибирскГородская муниципальная клиническая больница № 1, г. НовосибирскНИИ клинической иммунологии СО РАМН, г. НовосибирскThe relationship between various subpopulations of regulatory T-cells (Treg) and serum level of CA-125 and dynamics of Treg following surgery in ovarian cancer (OC) patients have been investigated. The typical for OC peripheral blood Treg changes (the enchantment of CD4+FoxP3+ и CD8+FoxP3+ T-cells and decrease of CD4+CD25+/CD4+CD25high Т-cells due to their migration to ascites) have been revealed only in patients with elevated CA-125 level and were not registered in patient's group with normal level of this antigen. CA-125 serum level was directly correlated to absolute count of CD4+CD25high Т-cells and was in reverse relation to CD8+FoxP3+ T-cells. Surgical removal of a tumor was accompanied by remarkable reduction of CA-125 level in all cases. However Treg changes were observed only in patients with optimal cytoreductive surgery and were evidenced by CD4+CD25+/CD4+CD25high Т-cell normalization, whereas the number of these cells in peripheral blood of patients with residual tumors after surgery remained decreased. At that percentage of CD4+FoxP3+ и CD8+FoxP3+ Т-cells 2 weeks after surgery was unchanged and their increased number was associated with persisted decrease of T-cell proliferation in response to anti-CD3 stimulation.https://www.mimmun.ru/mimmun/article/view/134tregfoxp3+са-125ovarian tumor mass |
| spellingShingle | E. R. Chernykh E. V. Kurganova M. A. Tikhonova E. G. Laskavaya V. A. Lebedeva A. A. Ostanin RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS Медицинская иммунология treg foxp3+ са-125 ovarian tumor mass |
| title | RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS |
| title_full | RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS |
| title_fullStr | RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS |
| title_full_unstemmed | RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS |
| title_short | RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS |
| title_sort | relation between regulatory t cells ca 125 level and tumor mass in ovarian cancer patients |
| topic | treg foxp3+ са-125 ovarian tumor mass |
| url | https://www.mimmun.ru/mimmun/article/view/134 |
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