Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis
Abstract Introduction The neutrophil-to-lymphocyte ratio (NLR) is a crucial prognosis predictor following several major operations. However, the association between NLR and the outcome after hip fracture surgery is unclear. In this meta-analysis, we investigated the correlation between NLR and posto...
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-021-02831-6 |
| _version_ | 1817997221626380288 |
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| author | Yu-Hang Chen Ching-Hsin Chou Hsin-Hsien Su Yu-Ting Tsai Ming-Hsiu Chiang Yi-Jie Kuo Yu-Pin Chen |
| author_facet | Yu-Hang Chen Ching-Hsin Chou Hsin-Hsien Su Yu-Ting Tsai Ming-Hsiu Chiang Yi-Jie Kuo Yu-Pin Chen |
| author_sort | Yu-Hang Chen |
| collection | DOAJ |
| description | Abstract Introduction The neutrophil-to-lymphocyte ratio (NLR) is a crucial prognosis predictor following several major operations. However, the association between NLR and the outcome after hip fracture surgery is unclear. In this meta-analysis, we investigated the correlation between NLR and postoperative mortality in geriatric patients following hip surgery. Method PubMed, Embase, Cochrane library, and Google Scholar were searched for studies up to June 2021 reporting the correlation between NLR and postoperative mortality in elderly patients undergoing surgery for hip fracture. Data from studies reporting the mean of NLR and its 95% confidence interval (CI) were pooled. Both long-term (≥ 1 year) and short-term (≤ 30 days) mortality rates were included for analysis. Result Eight retrospective studies comprising a total of 1563 patients were included. Both preoperative and postoperative NLRs (mean difference [MD]: 2.75, 95% CI: 0.23–5.27; P = 0.03 and MD: 2.36, 95% CI: 0.51–4.21; P = 0.01, respectively) were significantly higher in the long-term mortality group than in the long-term survival group. However, no significant differences in NLR were noted between the short-term mortality and survival groups (MD: − 1.02, 95% CI: − 3.98 to 1.93; P = 0.5). Conclusion Higher preoperative and postoperative NLRs were correlated with a higher risk of long-term mortality following surgery for hip fracture in the geriatric population, suggesting the prognostic value of NLR for long-term survival. Further studies with well-controlled confounders are warranted to clarify the predictive value of NLR in clinical practice in geriatric patients with hip fracture. |
| first_indexed | 2024-04-14T02:35:03Z |
| format | Article |
| id | doaj.art-ee5013c064824406af8806a7107874c3 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-14T02:35:03Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-ee5013c064824406af8806a7107874c32022-12-22T02:17:33ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2021-11-011611910.1186/s13018-021-02831-6Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysisYu-Hang Chen0Ching-Hsin Chou1Hsin-Hsien Su2Yu-Ting Tsai3Ming-Hsiu Chiang4Yi-Jie Kuo5Yu-Pin Chen6Department of General Medicine, Kaohsiung Chang Gung Memorial HospitalDepartment of General Medicine, Taipei Medical University HospitalDepartment of General Medicine, Kaohsiung Chang Gung Memorial HospitalDepartment of General Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationDepartment of General Medicine, Kaohsiung Chang Gung Memorial HospitalDepartment of Orthopedic Surgery, Wan Fang Hospital, Taipei Medical UniversityDepartment of Orthopedic Surgery, Wan Fang Hospital, Taipei Medical UniversityAbstract Introduction The neutrophil-to-lymphocyte ratio (NLR) is a crucial prognosis predictor following several major operations. However, the association between NLR and the outcome after hip fracture surgery is unclear. In this meta-analysis, we investigated the correlation between NLR and postoperative mortality in geriatric patients following hip surgery. Method PubMed, Embase, Cochrane library, and Google Scholar were searched for studies up to June 2021 reporting the correlation between NLR and postoperative mortality in elderly patients undergoing surgery for hip fracture. Data from studies reporting the mean of NLR and its 95% confidence interval (CI) were pooled. Both long-term (≥ 1 year) and short-term (≤ 30 days) mortality rates were included for analysis. Result Eight retrospective studies comprising a total of 1563 patients were included. Both preoperative and postoperative NLRs (mean difference [MD]: 2.75, 95% CI: 0.23–5.27; P = 0.03 and MD: 2.36, 95% CI: 0.51–4.21; P = 0.01, respectively) were significantly higher in the long-term mortality group than in the long-term survival group. However, no significant differences in NLR were noted between the short-term mortality and survival groups (MD: − 1.02, 95% CI: − 3.98 to 1.93; P = 0.5). Conclusion Higher preoperative and postoperative NLRs were correlated with a higher risk of long-term mortality following surgery for hip fracture in the geriatric population, suggesting the prognostic value of NLR for long-term survival. Further studies with well-controlled confounders are warranted to clarify the predictive value of NLR in clinical practice in geriatric patients with hip fracture.https://doi.org/10.1186/s13018-021-02831-6Hip fractureNeutrophil-to-lymphocyte ratioMortality |
| spellingShingle | Yu-Hang Chen Ching-Hsin Chou Hsin-Hsien Su Yu-Ting Tsai Ming-Hsiu Chiang Yi-Jie Kuo Yu-Pin Chen Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis Journal of Orthopaedic Surgery and Research Hip fracture Neutrophil-to-lymphocyte ratio Mortality |
| title | Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis |
| title_full | Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis |
| title_fullStr | Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis |
| title_full_unstemmed | Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis |
| title_short | Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis |
| title_sort | correlation between neutrophil to lymphocyte ratio and postoperative mortality in elderly patients with hip fracture a meta analysis |
| topic | Hip fracture Neutrophil-to-lymphocyte ratio Mortality |
| url | https://doi.org/10.1186/s13018-021-02831-6 |
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