Left ventricular systolic function changes in hypertrophic cardiomyopathy patients detected by the strain of different myocardium layers and longitudinal rotation
Abstract Background Impairment of left ventricular (LV) longitudinal function has an important role in hypertrophic cardiomyopathy (HCM). This research investigated an association between the longitudinal strain of different myocardial layers, longitudinal rotation and the LV systolic function of HC...
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BMC
2017-08-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12872-017-0651-x |
| _version_ | 1818286247792082944 |
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| author | Jun Huang Zi-Ning Yan Li Fan Yi-Fei Rui Xiang-Ting Song |
| author_facet | Jun Huang Zi-Ning Yan Li Fan Yi-Fei Rui Xiang-Ting Song |
| author_sort | Jun Huang |
| collection | DOAJ |
| description | Abstract Background Impairment of left ventricular (LV) longitudinal function has an important role in hypertrophic cardiomyopathy (HCM). This research investigated an association between the longitudinal strain of different myocardial layers, longitudinal rotation and the LV systolic function of HCM patients. Methods The research was performed on 36 HCM patients and 36 healthy subjects. The peak systolic longitudinal strain of the subendocardial, midmyocardial, and subepicardial layers was measured using 2-dimensional speckle tracking echocardiography (2D–STE). The apical long-axis and 4- and 2- chamber views were acquired via 2D Doppler echocardiography. The curve of the longitudinal rotation was traced at 17 timepoints in the analysis of 2 cardiac cycles. Results Compared with healthy subjects, in HCM patients regional LV peak systolic longitudinal strain was less, not only in hypertrophied LV myocardium, but also in non-hypertrophied myocardium. The rotational degrees of the midmyocardial-septal, apex, and lateral wall of HCM patients were significantly different from that of normal subjects, as follows. In HCM patients, clockwise longitudinal rotation was found. The interventricular septum thickness at end-diastole positively correlated with the peak longitudinal systolic strain of the subendocardial, the midmyocardial, and the subepicardial layers. The area under ROC curve values for subendocardial, midmyocardial and subepicardial layers in HCM patients were 0.923, 0.938, 0.948. Conclusion In HCM patients, the longitudinal function was damaged, even with normal LV ejection fraction. The peak longitudinal systolic strain of the subendocardial, midmyocardial, and subepicardial layers, and the longitudinal rotation detected by 2D–STE, are very sensitive predictors of systolic function in patients with HCM. |
| first_indexed | 2024-12-13T01:21:34Z |
| format | Article |
| id | doaj.art-ee50c2664e3d4a05bb65c8987a015756 |
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| language | English |
| last_indexed | 2024-12-13T01:21:34Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-ee50c2664e3d4a05bb65c8987a0157562022-12-22T00:04:13ZengBMCBMC Cardiovascular Disorders1471-22612017-08-0117111010.1186/s12872-017-0651-xLeft ventricular systolic function changes in hypertrophic cardiomyopathy patients detected by the strain of different myocardium layers and longitudinal rotationJun Huang0Zi-Ning Yan1Li Fan2Yi-Fei Rui3Xiang-Ting Song4Department of Echocardiography, ChangZhou No.2 People’s Hospital Affiliated to NanJing Medical UniversityDepartment of Echocardiography, ChangZhou No.2 People’s Hospital Affiliated to NanJing Medical UniversityDepartment of Echocardiography, ChangZhou No.2 People’s Hospital Affiliated to NanJing Medical UniversityDepartment of Echocardiography, ChangZhou No.2 People’s Hospital Affiliated to NanJing Medical UniversityDepartment of Echocardiography, ChangZhou No.2 People’s Hospital Affiliated to NanJing Medical UniversityAbstract Background Impairment of left ventricular (LV) longitudinal function has an important role in hypertrophic cardiomyopathy (HCM). This research investigated an association between the longitudinal strain of different myocardial layers, longitudinal rotation and the LV systolic function of HCM patients. Methods The research was performed on 36 HCM patients and 36 healthy subjects. The peak systolic longitudinal strain of the subendocardial, midmyocardial, and subepicardial layers was measured using 2-dimensional speckle tracking echocardiography (2D–STE). The apical long-axis and 4- and 2- chamber views were acquired via 2D Doppler echocardiography. The curve of the longitudinal rotation was traced at 17 timepoints in the analysis of 2 cardiac cycles. Results Compared with healthy subjects, in HCM patients regional LV peak systolic longitudinal strain was less, not only in hypertrophied LV myocardium, but also in non-hypertrophied myocardium. The rotational degrees of the midmyocardial-septal, apex, and lateral wall of HCM patients were significantly different from that of normal subjects, as follows. In HCM patients, clockwise longitudinal rotation was found. The interventricular septum thickness at end-diastole positively correlated with the peak longitudinal systolic strain of the subendocardial, the midmyocardial, and the subepicardial layers. The area under ROC curve values for subendocardial, midmyocardial and subepicardial layers in HCM patients were 0.923, 0.938, 0.948. Conclusion In HCM patients, the longitudinal function was damaged, even with normal LV ejection fraction. The peak longitudinal systolic strain of the subendocardial, midmyocardial, and subepicardial layers, and the longitudinal rotation detected by 2D–STE, are very sensitive predictors of systolic function in patients with HCM.http://link.springer.com/article/10.1186/s12872-017-0651-xLeft ventricularHypertrophic cardiomyopathyStrainLongitudinal rotation |
| spellingShingle | Jun Huang Zi-Ning Yan Li Fan Yi-Fei Rui Xiang-Ting Song Left ventricular systolic function changes in hypertrophic cardiomyopathy patients detected by the strain of different myocardium layers and longitudinal rotation BMC Cardiovascular Disorders Left ventricular Hypertrophic cardiomyopathy Strain Longitudinal rotation |
| title | Left ventricular systolic function changes in hypertrophic cardiomyopathy patients detected by the strain of different myocardium layers and longitudinal rotation |
| title_full | Left ventricular systolic function changes in hypertrophic cardiomyopathy patients detected by the strain of different myocardium layers and longitudinal rotation |
| title_fullStr | Left ventricular systolic function changes in hypertrophic cardiomyopathy patients detected by the strain of different myocardium layers and longitudinal rotation |
| title_full_unstemmed | Left ventricular systolic function changes in hypertrophic cardiomyopathy patients detected by the strain of different myocardium layers and longitudinal rotation |
| title_short | Left ventricular systolic function changes in hypertrophic cardiomyopathy patients detected by the strain of different myocardium layers and longitudinal rotation |
| title_sort | left ventricular systolic function changes in hypertrophic cardiomyopathy patients detected by the strain of different myocardium layers and longitudinal rotation |
| topic | Left ventricular Hypertrophic cardiomyopathy Strain Longitudinal rotation |
| url | http://link.springer.com/article/10.1186/s12872-017-0651-x |
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