scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells
Relationships between DNA methylation and transcription, and methylation and DNA accessibility can be probed but interrogating all three in the same single cells has not been possible. Here, the authors report the first single-cell method for parallel chromatin accessibility, DNA methylation and tra...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03149-4 |
| _version_ | 1818420120629805056 |
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| author | Stephen J. Clark Ricard Argelaguet Chantriolnt-Andreas Kapourani Thomas M. Stubbs Heather J. Lee Celia Alda-Catalinas Felix Krueger Guido Sanguinetti Gavin Kelsey John C. Marioni Oliver Stegle Wolf Reik |
| author_facet | Stephen J. Clark Ricard Argelaguet Chantriolnt-Andreas Kapourani Thomas M. Stubbs Heather J. Lee Celia Alda-Catalinas Felix Krueger Guido Sanguinetti Gavin Kelsey John C. Marioni Oliver Stegle Wolf Reik |
| author_sort | Stephen J. Clark |
| collection | DOAJ |
| description | Relationships between DNA methylation and transcription, and methylation and DNA accessibility can be probed but interrogating all three in the same single cells has not been possible. Here, the authors report the first single-cell method for parallel chromatin accessibility, DNA methylation and transcriptome profiling. |
| first_indexed | 2024-12-14T12:49:25Z |
| format | Article |
| id | doaj.art-ee5160af085446eb92ec31544e77c471 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T12:49:25Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ee5160af085446eb92ec31544e77c4712022-12-21T23:00:43ZengNature PortfolioNature Communications2041-17232018-02-01911910.1038/s41467-018-03149-4scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cellsStephen J. Clark0Ricard Argelaguet1Chantriolnt-Andreas Kapourani2Thomas M. Stubbs3Heather J. Lee4Celia Alda-Catalinas5Felix Krueger6Guido Sanguinetti7Gavin Kelsey8John C. Marioni9Oliver Stegle10Wolf Reik11Epigenetics Programme, Babraham InstituteEuropean Molecular Biology Laboratory, European Bioinformatics InstituteSchool of Informatics, University of EdinburghEpigenetics Programme, Babraham InstituteEpigenetics Programme, Babraham InstituteEpigenetics Programme, Babraham InstituteBioinformatics Group, Babraham InstituteSchool of Informatics, University of EdinburghEpigenetics Programme, Babraham InstituteEuropean Molecular Biology Laboratory, European Bioinformatics InstituteEuropean Molecular Biology Laboratory, European Bioinformatics InstituteEpigenetics Programme, Babraham InstituteRelationships between DNA methylation and transcription, and methylation and DNA accessibility can be probed but interrogating all three in the same single cells has not been possible. Here, the authors report the first single-cell method for parallel chromatin accessibility, DNA methylation and transcriptome profiling.https://doi.org/10.1038/s41467-018-03149-4 |
| spellingShingle | Stephen J. Clark Ricard Argelaguet Chantriolnt-Andreas Kapourani Thomas M. Stubbs Heather J. Lee Celia Alda-Catalinas Felix Krueger Guido Sanguinetti Gavin Kelsey John C. Marioni Oliver Stegle Wolf Reik scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells Nature Communications |
| title | scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells |
| title_full | scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells |
| title_fullStr | scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells |
| title_full_unstemmed | scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells |
| title_short | scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells |
| title_sort | scnmt seq enables joint profiling of chromatin accessibility dna methylation and transcription in single cells |
| url | https://doi.org/10.1038/s41467-018-03149-4 |
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