How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives
Chronic heart failure (CHF) is a disease with important clinical and socio-economic ramifications. Malnutrition and severe alteration of the protein components of the body (protein disarrangements), common conditions in CHF patients, are independent correlates of heart dysfunction, disease progressi...
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/7/3332 |
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| author | Giovanni Corsetti Evasio Pasini Claudia Romano Carol Chen-Scarabelli Tiziano M. Scarabelli Vincenzo Flati Louis Saravolatz Francesco S. Dioguardi |
| author_facet | Giovanni Corsetti Evasio Pasini Claudia Romano Carol Chen-Scarabelli Tiziano M. Scarabelli Vincenzo Flati Louis Saravolatz Francesco S. Dioguardi |
| author_sort | Giovanni Corsetti |
| collection | DOAJ |
| description | Chronic heart failure (CHF) is a disease with important clinical and socio-economic ramifications. Malnutrition and severe alteration of the protein components of the body (protein disarrangements), common conditions in CHF patients, are independent correlates of heart dysfunction, disease progression, and mortality. Autophagy, a prominent occurrence in the heart of patients with advanced CHF, is a self-digestive process that prolongs myocardial cell lifespan by the removal of cytosolic components, such as aging organelles and proteins, and recycles the constituent elements for new protein synthesis. However, in specific conditions, excessive activation of autophagy can lead to the destruction of molecules and organelles essential to cell survival, ultimately leading to organ failure and patient death. In this review, we aim to describe the experimental and clinical evidence supporting a pathophysiological role of nutrition and autophagy in the progression of CHF. The understanding of the mechanisms underlying the interplay between nutrition and autophagy may have important clinical implications by providing molecular targets for innovative therapeutic strategies in CHF patients. |
| first_indexed | 2024-03-10T12:56:38Z |
| format | Article |
| id | doaj.art-ee5268f8d25b409db9833cc316a8189a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:56:38Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ee5268f8d25b409db9833cc316a8189a2023-11-21T11:52:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01227333210.3390/ijms22073332How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and PerspectivesGiovanni Corsetti0Evasio Pasini1Claudia Romano2Carol Chen-Scarabelli3Tiziano M. Scarabelli4Vincenzo Flati5Louis Saravolatz6Francesco S. Dioguardi7Department of Clinical and Experimental Sciences, Division of Human Anatomy and Physiopathology, University of Brescia, 25123 Brescia, ItalyCardiac Rehabilitation Division, Scientific Clinical Institutes Maugeri (IRCCS), Lumezzane, 25065 Brescia, ItalyDepartment of Clinical and Experimental Sciences, Division of Human Anatomy and Physiopathology, University of Brescia, 25123 Brescia, ItalyHunter Holmes McGuire Veterans Affairs Medical Centre (VAMC), Division of Cardiology, Richmond, VA 23249, USACentre for Heart and Vessel Preclinical Studies at St. John Hospital and Medical Centre, Wayne State University, Detroit, MI 48202, USADepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Medicine at St. John Hospital, Wayne State University, Detroit, MI 48202, USADepartment of Internal Medicine, University of Cagliari, 09124 Cagliari, ItalyChronic heart failure (CHF) is a disease with important clinical and socio-economic ramifications. Malnutrition and severe alteration of the protein components of the body (protein disarrangements), common conditions in CHF patients, are independent correlates of heart dysfunction, disease progression, and mortality. Autophagy, a prominent occurrence in the heart of patients with advanced CHF, is a self-digestive process that prolongs myocardial cell lifespan by the removal of cytosolic components, such as aging organelles and proteins, and recycles the constituent elements for new protein synthesis. However, in specific conditions, excessive activation of autophagy can lead to the destruction of molecules and organelles essential to cell survival, ultimately leading to organ failure and patient death. In this review, we aim to describe the experimental and clinical evidence supporting a pathophysiological role of nutrition and autophagy in the progression of CHF. The understanding of the mechanisms underlying the interplay between nutrition and autophagy may have important clinical implications by providing molecular targets for innovative therapeutic strategies in CHF patients.https://www.mdpi.com/1422-0067/22/7/3332malnutritionautophagyheart failurechronic diseasesamino acids |
| spellingShingle | Giovanni Corsetti Evasio Pasini Claudia Romano Carol Chen-Scarabelli Tiziano M. Scarabelli Vincenzo Flati Louis Saravolatz Francesco S. Dioguardi How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives International Journal of Molecular Sciences malnutrition autophagy heart failure chronic diseases amino acids |
| title | How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives |
| title_full | How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives |
| title_fullStr | How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives |
| title_full_unstemmed | How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives |
| title_short | How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives |
| title_sort | how can malnutrition affect autophagy in chronic heart failure focus and perspectives |
| topic | malnutrition autophagy heart failure chronic diseases amino acids |
| url | https://www.mdpi.com/1422-0067/22/7/3332 |
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