Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives
Bioactive nanomaterials are increasingly being applied in oral health research. Specifically, they have shown great potential for periodontal tissue regeneration and have substantially improved oral health in translational and clinical applications. However, their limitations and side effects still...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/6/290 |
| _version_ | 1797594100488208384 |
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| author | Chen Zong Annelies Bronckaers Guy Willems Hong He Maria Cadenas de Llano-Pérula |
| author_facet | Chen Zong Annelies Bronckaers Guy Willems Hong He Maria Cadenas de Llano-Pérula |
| author_sort | Chen Zong |
| collection | DOAJ |
| description | Bioactive nanomaterials are increasingly being applied in oral health research. Specifically, they have shown great potential for periodontal tissue regeneration and have substantially improved oral health in translational and clinical applications. However, their limitations and side effects still need to be explored and elucidated. This article aims to review the recent advancements in nanomaterials applied for periodontal tissue regeneration and to discuss future research directions in this field, especially focusing on research using nanomaterials to improve oral health. The biomimetic and physiochemical properties of nanomaterials such as metals and polymer composites are described in detail, including their effects on the regeneration of alveolar bone, periodontal ligament, cementum and gingiva. Finally, the biomedical safety issues of their application as regenerative materials are updated, with a discussion about their complications and future perspectives. Although the applications of bioactive nanomaterials in the oral cavity are still at an initial stage, and pose numerous challenges, recent research suggests that they are a promising alternative in periodontal tissue regeneration. |
| first_indexed | 2024-03-11T02:18:56Z |
| format | Article |
| id | doaj.art-ee534487f9b4481f8ef470a3d6113d59 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-11T02:18:56Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-ee534487f9b4481f8ef470a3d6113d592023-11-18T11:03:00ZengMDPI AGJournal of Functional Biomaterials2079-49832023-05-0114629010.3390/jfb14060290Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future PerspectivesChen Zong0Annelies Bronckaers1Guy Willems2Hong He3Maria Cadenas de Llano-Pérula4Department of Oral Health Sciences-Orthodontics, University of Leuven (KU Leuven) and Dentistry, University Hospitals Leuven, 3000 Leuven, BelgiumBiomedical Research Institute, Faculty of Life Sciences, University of Hasselt, 3590 Diepenbeek, BelgiumDepartment of Oral Health Sciences-Orthodontics, University of Leuven (KU Leuven) and Dentistry, University Hospitals Leuven, 3000 Leuven, BelgiumThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaDepartment of Oral Health Sciences-Orthodontics, University of Leuven (KU Leuven) and Dentistry, University Hospitals Leuven, 3000 Leuven, BelgiumBioactive nanomaterials are increasingly being applied in oral health research. Specifically, they have shown great potential for periodontal tissue regeneration and have substantially improved oral health in translational and clinical applications. However, their limitations and side effects still need to be explored and elucidated. This article aims to review the recent advancements in nanomaterials applied for periodontal tissue regeneration and to discuss future research directions in this field, especially focusing on research using nanomaterials to improve oral health. The biomimetic and physiochemical properties of nanomaterials such as metals and polymer composites are described in detail, including their effects on the regeneration of alveolar bone, periodontal ligament, cementum and gingiva. Finally, the biomedical safety issues of their application as regenerative materials are updated, with a discussion about their complications and future perspectives. Although the applications of bioactive nanomaterials in the oral cavity are still at an initial stage, and pose numerous challenges, recent research suggests that they are a promising alternative in periodontal tissue regeneration.https://www.mdpi.com/2079-4983/14/6/290nanomaterialsperiodontal regenerationalveolar boneperiodontal ligamentcementumgingiva |
| spellingShingle | Chen Zong Annelies Bronckaers Guy Willems Hong He Maria Cadenas de Llano-Pérula Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives Journal of Functional Biomaterials nanomaterials periodontal regeneration alveolar bone periodontal ligament cementum gingiva |
| title | Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives |
| title_full | Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives |
| title_fullStr | Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives |
| title_full_unstemmed | Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives |
| title_short | Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives |
| title_sort | nanomaterials for periodontal tissue regeneration progress challenges and future perspectives |
| topic | nanomaterials periodontal regeneration alveolar bone periodontal ligament cementum gingiva |
| url | https://www.mdpi.com/2079-4983/14/6/290 |
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