Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides
Ceramides are a class of sphingolipids which have recently been shown to be better cardiovascular disease (CVD) risk predictors than traditional CVD risk biomarkers. Tyrosol (TYR) is a dietary phenolic compound known to possess cardioprotective effects per se or through its in vivo active metabolite...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/11/1679 |
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| author | Jose Rodríguez-Morató Anna Boronat Gabriele Serreli Laura Enríquez Alex Gomez-Gomez Oscar J. Pozo Montserrat Fitó Rafael de la Torre |
| author_facet | Jose Rodríguez-Morató Anna Boronat Gabriele Serreli Laura Enríquez Alex Gomez-Gomez Oscar J. Pozo Montserrat Fitó Rafael de la Torre |
| author_sort | Jose Rodríguez-Morató |
| collection | DOAJ |
| description | Ceramides are a class of sphingolipids which have recently been shown to be better cardiovascular disease (CVD) risk predictors than traditional CVD risk biomarkers. Tyrosol (TYR) is a dietary phenolic compound known to possess cardioprotective effects per se or through its in vivo active metabolite hydroxytyrosol. The purpose of this study was to evaluate the effects of the co-administration of white wine (WW) and TYR on circulating levels of ceramides and other lipids in humans at high CVD risk. Volunteers underwent a randomized controlled crossover clinical trial (4-week duration per intervention) with three different interventions: control, WW, and WW enriched with a capsule of TYR (WW + TYR). Endothelial function cardiovascular biomarkers and plasma lipidomic profile were assessed before and after each intervention. It was found that the WW + TYR intervention resulted in lower levels of three ceramide ratios, associated with an improvement of endothelial function (Cer C16:0/Cer C24:0, Cer C18:0/Cer C24:0, and Cer C24:1/Cer C24:0), when compared to the control intervention. Moreover, WW + TYR was able to minimize the alterations in plasma diacylglycerols concentrations observed following WW. Overall, the results obtained show that the antioxidant TYR administered with WW exerts beneficial effects at the cardiovascular level, in part by modulating blood lipid profile. |
| first_indexed | 2024-03-10T05:45:41Z |
| format | Article |
| id | doaj.art-ee5522373c454fc7b1a07080a30de47d |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T05:45:41Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-ee5522373c454fc7b1a07080a30de47d2023-11-22T22:12:06ZengMDPI AGAntioxidants2076-39212021-10-011011167910.3390/antiox10111679Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of CeramidesJose Rodríguez-Morató0Anna Boronat1Gabriele Serreli2Laura Enríquez3Alex Gomez-Gomez4Oscar J. Pozo5Montserrat Fitó6Rafael de la Torre7Integrative Pharmacology and Systems Neuroscience Research Group, IMIM (Hospital del Mar Medical Research Institute), Dr. Aiguader 88, 08003 Barcelona, SpainIntegrative Pharmacology and Systems Neuroscience Research Group, IMIM (Hospital del Mar Medical Research Institute), Dr. Aiguader 88, 08003 Barcelona, SpainDepartment of Biomedical Sciences, University of Cagliari, Cittadella Universitaria SS 554, 09042 Monserrato, ItalyIntegrative Pharmacology and Systems Neuroscience Research Group, IMIM (Hospital del Mar Medical Research Institute), Dr. Aiguader 88, 08003 Barcelona, SpainDepartment of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, 08003 Barcelona, SpainDepartment of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, 08003 Barcelona, SpainSpanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, SpainIntegrative Pharmacology and Systems Neuroscience Research Group, IMIM (Hospital del Mar Medical Research Institute), Dr. Aiguader 88, 08003 Barcelona, SpainCeramides are a class of sphingolipids which have recently been shown to be better cardiovascular disease (CVD) risk predictors than traditional CVD risk biomarkers. Tyrosol (TYR) is a dietary phenolic compound known to possess cardioprotective effects per se or through its in vivo active metabolite hydroxytyrosol. The purpose of this study was to evaluate the effects of the co-administration of white wine (WW) and TYR on circulating levels of ceramides and other lipids in humans at high CVD risk. Volunteers underwent a randomized controlled crossover clinical trial (4-week duration per intervention) with three different interventions: control, WW, and WW enriched with a capsule of TYR (WW + TYR). Endothelial function cardiovascular biomarkers and plasma lipidomic profile were assessed before and after each intervention. It was found that the WW + TYR intervention resulted in lower levels of three ceramide ratios, associated with an improvement of endothelial function (Cer C16:0/Cer C24:0, Cer C18:0/Cer C24:0, and Cer C24:1/Cer C24:0), when compared to the control intervention. Moreover, WW + TYR was able to minimize the alterations in plasma diacylglycerols concentrations observed following WW. Overall, the results obtained show that the antioxidant TYR administered with WW exerts beneficial effects at the cardiovascular level, in part by modulating blood lipid profile.https://www.mdpi.com/2076-3921/10/11/1679cardiovascular diseaseceramidesethanolrandomized clinical trialtyrosolwhite wine |
| spellingShingle | Jose Rodríguez-Morató Anna Boronat Gabriele Serreli Laura Enríquez Alex Gomez-Gomez Oscar J. Pozo Montserrat Fitó Rafael de la Torre Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides Antioxidants cardiovascular disease ceramides ethanol randomized clinical trial tyrosol white wine |
| title | Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides |
| title_full | Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides |
| title_fullStr | Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides |
| title_full_unstemmed | Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides |
| title_short | Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides |
| title_sort | effects of wine and tyrosol on the lipid metabolic profile of subjects at risk of cardiovascular disease potential cardioprotective role of ceramides |
| topic | cardiovascular disease ceramides ethanol randomized clinical trial tyrosol white wine |
| url | https://www.mdpi.com/2076-3921/10/11/1679 |
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