Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis
Microtubules, components of the cytosqueleton, play an important role in cell division, cell migration and thus in the cancer proccess through dynamic instability. Therefore they are an important target for anti-cancer treatment. Proper modelling of dynamic instability is a crucial tool to understan...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2015-01-01
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| Series: | ITM Web of Conferences |
| Online Access: | http://dx.doi.org/10.1051/itmconf/20150500011 |
| Summary: | Microtubules, components of the cytosqueleton, play an important role in cell division, cell migration and thus in the cancer proccess through dynamic instability. Therefore they are an important target for anti-cancer treatment. Proper modelling of dynamic instability is a crucial tool to understand the mechanism of action of microtubule targeting agents. In this paper, we propose a new concept for GTP-tubulin hydrolysis which allow the model to accurately reproduce microtubule dynamics observed in vitro or in cells. This approach will be more appropriate to take study the effects of drugs. |
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| ISSN: | 2271-2097 |