Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis
Microtubules, components of the cytosqueleton, play an important role in cell division, cell migration and thus in the cancer proccess through dynamic instability. Therefore they are an important target for anti-cancer treatment. Proper modelling of dynamic instability is a crucial tool to understan...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2015-01-01
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| Series: | ITM Web of Conferences |
| Online Access: | http://dx.doi.org/10.1051/itmconf/20150500011 |
| _version_ | 1828888021586411520 |
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| author | Barlukova Ayuna Honoré Stéphane Hubert Florence |
| author_facet | Barlukova Ayuna Honoré Stéphane Hubert Florence |
| author_sort | Barlukova Ayuna |
| collection | DOAJ |
| description | Microtubules, components of the cytosqueleton, play an important role in cell division, cell migration and thus in the cancer proccess through dynamic instability. Therefore they are an important target for anti-cancer treatment. Proper modelling of dynamic instability is a crucial tool to understand the mechanism of action of microtubule targeting agents. In this paper, we propose a new concept for GTP-tubulin hydrolysis which allow the model to accurately reproduce microtubule dynamics observed in vitro or in cells. This approach will be more appropriate to take study the effects of drugs. |
| first_indexed | 2024-12-13T12:15:09Z |
| format | Article |
| id | doaj.art-ee568e91eadf4ed9a265569e8e6fa037 |
| institution | Directory Open Access Journal |
| issn | 2271-2097 |
| language | English |
| last_indexed | 2024-12-13T12:15:09Z |
| publishDate | 2015-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | ITM Web of Conferences |
| spelling | doaj.art-ee568e91eadf4ed9a265569e8e6fa0372022-12-21T23:46:44ZengEDP SciencesITM Web of Conferences2271-20972015-01-0150001110.1051/itmconf/20150500011itmconf_mod2015_00011Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysisBarlukova Ayuna0Honoré Stéphane1Hubert Florence2Aix-Marseille University, CNRS, Centrale MarseilleAix-Marseille University, INSERM, CRO2Aix-Marseille University, CNRS, Centrale MarseilleMicrotubules, components of the cytosqueleton, play an important role in cell division, cell migration and thus in the cancer proccess through dynamic instability. Therefore they are an important target for anti-cancer treatment. Proper modelling of dynamic instability is a crucial tool to understand the mechanism of action of microtubule targeting agents. In this paper, we propose a new concept for GTP-tubulin hydrolysis which allow the model to accurately reproduce microtubule dynamics observed in vitro or in cells. This approach will be more appropriate to take study the effects of drugs.http://dx.doi.org/10.1051/itmconf/20150500011 |
| spellingShingle | Barlukova Ayuna Honoré Stéphane Hubert Florence Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis ITM Web of Conferences |
| title | Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis |
| title_full | Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis |
| title_fullStr | Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis |
| title_full_unstemmed | Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis |
| title_short | Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis |
| title_sort | mathematical modeling of the microtubule dynamic instability a new approch of gtp tubulin hydrolysis |
| url | http://dx.doi.org/10.1051/itmconf/20150500011 |
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